PMID- 19683237
OWN - NLM
STAT- MEDLINE
DCOM- 20100415
LR  - 20100201
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 208
IP  - 2
DP  - 2010 Feb
TI  - Lysyl oxidase resolves inflammation by reducing monocyte chemoattractant 
      protein-1 in abdominal aortic aneurysm.
PG  - 366-9
LID - 10.1016/j.atherosclerosis.2009.07.036 [doi]
AB  - Lysyl oxidase (LOX) is an enzyme critical for the stability of extracellular 
      matrix and also known to have diverse biological functions. Little is known, 
      however, about the role of LOX in regulating inflammation. Here we demonstrate 
      that LOX suppresses secretion of monocyte chemoattractant protein-1 (MCP-1) in 
      cultured vascular smooth muscle cells. Furthermore, enhancement of LOX activity 
      reduces MCP-1 in a mouse model of abdominal aortic aneurysm (AAA), thereby 
      preventing macrophage infiltration and AAA progression. These findings suggest 
      that LOX has a novel function in resolving inflammation by reducing MCP-1 in AAA.
CI  - Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Onoda, Masahiko
AU  - Onoda M
AD  - Department of Surgery and Clinical Science, Yamaguchi University Graduate School 
      of Medicine, 1-1-1 Minami Kogushi, Ube, Japan.
FAU - Yoshimura, Koichi
AU  - Yoshimura K
FAU - Aoki, Hiroki
AU  - Aoki H
FAU - Ikeda, Yasuhiro
AU  - Ikeda Y
FAU - Morikage, Noriyasu
AU  - Morikage N
FAU - Furutani, Akira
AU  - Furutani A
FAU - Matsuzaki, Masunori
AU  - Matsuzaki M
FAU - Hamano, Kimikazu
AU  - Hamano K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090723
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - EC 1.4.3.13 (Protein-Lysine 6-Oxidase)
SB  - IM
MH  - Adenoviridae/metabolism
MH  - Animals
MH  - Aortic Aneurysm, Abdominal/*metabolism/therapy
MH  - Chemokine CCL2/*metabolism
MH  - Cytokines/metabolism
MH  - Disease Progression
MH  - Inflammation
MH  - Macrophages/metabolism
MH  - Male
MH  - Mice
MH  - Muscle, Smooth, Vascular/cytology
MH  - Protein-Lysine 6-Oxidase/metabolism/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2009/08/18 09:00
MHDA- 2010/04/16 06:00
CRDT- 2009/08/18 09:00
PHST- 2009/04/21 00:00 [received]
PHST- 2009/07/14 00:00 [revised]
PHST- 2009/07/15 00:00 [accepted]
PHST- 2009/08/18 09:00 [entrez]
PHST- 2009/08/18 09:00 [pubmed]
PHST- 2010/04/16 06:00 [medline]
AID - S0021-9150(09)00601-7 [pii]
AID - 10.1016/j.atherosclerosis.2009.07.036 [doi]
PST - ppublish
SO  - Atherosclerosis. 2010 Feb;208(2):366-9. doi: 
      10.1016/j.atherosclerosis.2009.07.036. Epub 2009 Jul 23.