PMID- 19683555
OWN - NLM
STAT- MEDLINE
DCOM- 20091130
LR  - 20091020
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 70
IP  - 11
DP  - 2009 Nov
TI  - Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and 
      cytokine gene polymorphisms in leptospirosis.
PG  - 915-20
LID - 10.1016/j.humimm.2009.08.007 [doi]
AB  - Leptospirosis is an emerging zoonotic disease caused by pathogenic species of the 
      genus Leptospira. It has a broad range of clinical presentations in humans. 
      Although progress has been made in the characterization of the host immune system 
      factors that may affect disease progression and outcome, to date few reports have 
      addressed the role of genetic polymorphisms in the susceptibility to 
      leptospirosis. In this work a group of patients with a history of leptospiral 
      infection and a control group were compared for polymorphisms in the human 
      leukocyte antigen (HLA), in killer-cell immunoglobulin-like receptors (KIR), and 
      in cytokine genes. Alleles in the HLA-A and -B loci were associated with 
      susceptibility, as were the class I haplotype A*01-B*08-Cw*07 and the 8.1 
      ancestral haplotype (A*01-B*08-Cw*07-DRB1*03-DQB1*02). Single nucleotide 
      polymorphisms in the interleukin (IL)-4 and IL-4Ralpha genes also had 
      significantly higher frequencies in the patient group. No association was 
      reported between KIR gene profile and leptospirosis. This work highlights the 
      importance of using genetic polymorphisms to better understand the mechanisms 
      involved in the immune response to leptospirosis.
FAU - Fialho, Raquel Nunes
AU  - Fialho RN
AD  - Servico Especializado de Epidemiologia e Biologia Molecular, Hospital de Santo 
      Espirito de Angra do Heroismo, Angra do Heroismo, Azores, Portugal.
FAU - Martins, Luis
AU  - Martins L
FAU - Pinheiro, Joao Paulo
AU  - Pinheiro JP
FAU - Bettencourt, Bruno Filipe
AU  - Bettencourt BF
FAU - Couto, Ana Rita
AU  - Couto AR
FAU - Santos, Margarida Rodrigues
AU  - Santos MR
FAU - Peixoto, Maria Jose
AU  - Peixoto MJ
FAU - Garrett, Francisco
AU  - Garrett F
FAU - Leal, Joao
AU  - Leal J
FAU - Tomas, Ana Maria
AU  - Tomas AM
FAU - Bruges-Armas, Jacome
AU  - Bruges-Armas J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090813
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Cytokines)
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Alleles
MH  - Cytokines/*genetics/immunology
MH  - Genotype
MH  - HLA Antigens/*genetics/immunology
MH  - Humans
MH  - Leptospirosis/*genetics/*immunology
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Receptors, KIR/*genetics/immunology
EDAT- 2009/08/18 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/08/18 09:00
PHST- 2008/11/28 00:00 [received]
PHST- 2009/07/27 00:00 [revised]
PHST- 2009/08/10 00:00 [accepted]
PHST- 2009/08/18 09:00 [entrez]
PHST- 2009/08/18 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - S0198-8859(09)00219-5 [pii]
AID - 10.1016/j.humimm.2009.08.007 [doi]
PST - ppublish
SO  - Hum Immunol. 2009 Nov;70(11):915-20. doi: 10.1016/j.humimm.2009.08.007. Epub 2009 
      Aug 13.