PMID- 19684244
OWN - NLM
STAT- MEDLINE
DCOM- 20100628
LR  - 20220309
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Linking)
VI  - 20
IP  - 5
DP  - 2010 May
TI  - Ontogeny of progesterone receptor expression in the subplate of fetal and 
      neonatal rat cortex.
PG  - 1046-52
LID - 10.1093/cercor/bhp165 [doi]
AB  - The progesterone receptor (PR) is transiently expressed in the rat cortex during 
      development and its expression is initiated in the developmentally critical 
      layer, the subplate. As subplate neurons pioneer thalamocortical and corticofugal 
      connectivity, the expression of PR in this layer suggests an important function 
      for PR in cortical development. Using immunocytochemistry for PR, the present 
      study determined the precise ontogeny of PR expression in subplate neurons. The 
      number of cells containing PR immunoreactivity (PRir) within the subplate was 
      quantified from embryonic day (E) 17 through postnatal day (P) 14. The subplate 
      was positively identified by the marker calretinin and by BrDU birthdating. The 
      results demonstrate that PRir is undetectable in fetal cortex on E17, but is 
      first observed in the subplate on E18. The number of PRir cells peaks on P2 and 
      then steadily declines, until PRir is once again not detectable in subplate by 
      P14. This developmental window of PR expression within the subplate coincides 
      with establishment of early cortical circuitry and the gradual demise of subplate 
      cells, suggesting that PR may play a critical role in mediating these fundamental 
      developmental processes.
FAU - Jahagirdar, Vaishali
AU  - Jahagirdar V
AD  - Department of Psychology and Center for Neuroscience Research, University at 
      Albany-State University of New York, Albany, NY 12222, USA.
FAU - Wagner, Christine K
AU  - Wagner CK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20090814
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
RN  - 0 (Calb2 protein, rat)
RN  - 0 (Calbindin 2)
RN  - 0 (Receptors, Progesterone)
RN  - 0 (S100 Calcium Binding Protein G)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Bromodeoxyuridine/metabolism
MH  - Calbindin 2
MH  - *Cerebral Cortex/embryology/growth & development/metabolism
MH  - Embryo, Mammalian
MH  - Female
MH  - Gene Expression Regulation, Developmental/*physiology
MH  - Male
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Progesterone/genetics/*metabolism
MH  - S100 Calcium Binding Protein G/metabolism
EDAT- 2009/08/18 09:00
MHDA- 2010/06/29 06:00
CRDT- 2009/08/18 09:00
PHST- 2009/08/18 09:00 [entrez]
PHST- 2009/08/18 09:00 [pubmed]
PHST- 2010/06/29 06:00 [medline]
AID - bhp165 [pii]
AID - 10.1093/cercor/bhp165 [doi]
PST - ppublish
SO  - Cereb Cortex. 2010 May;20(5):1046-52. doi: 10.1093/cercor/bhp165. Epub 2009 Aug 
      14.