PMID- 19684254
OWN - NLM
STAT- MEDLINE
DCOM- 20091130
LR  - 20221207
IS  - 1521-0103 (Electronic)
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 331
IP  - 2
DP  - 2009 Nov
TI  - Discriminative stimulus effects of psychostimulants and hallucinogens in 
      S(+)-3,4-methylenedioxymethamphetamine (MDMA) and R(-)-MDMA trained mice.
PG  - 717-23
LID - 10.1124/jpet.109.156174 [doi]
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) is a substituted phenethylamine more 
      commonly known as the drug of abuse "ecstasy." The acute and persistent 
      neurochemical effects of MDMA in the mice are distinct from those in other 
      species. MDMA shares biological effects with both amphetamine-type stimulants and 
      mescaline-type hallucinogens, which may be attributable to distinct effects of 
      its two enantiomers, both of which are active in vivo. In this regard, among the 
      substituted phenethylamines, R(-)-enantiomers tend to have hallucinogen-like 
      effects, whereas S(+)-enantiomers tend to have stimulant-like effects. In the 
      present study, mice were trained to discriminate S(+)- or R(-)-MDMA from vehicle. 
      Drug substitution tests were then undertaken with the structurally similar 
      phenethylamine dopamine/norepinephrine releaser S(+)-amphetamine, the 
      structurally dissimilar tropane nonselective monoamine reuptake inhibitor 
      cocaine, the structurally similar phenethylamine 5-hydroxytryptamine (5-HT)(2A) 
      agonist 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7), and the 
      structurally dissimilar mixed action tryptamine 5-HT(2A) agonist/monoamine 
      reuptake inhibitor N,N-dipropyltryptamine (DPT). S(+)-amphetamine fully 
      substituted in the S(+)-MDMA-treated animals but did not substitute for the 
      R(-)-MDMA cue. 2C-T-7 fully substituted in the R(-)-MDMA-trained animals but did 
      not substitute for the S(+)-MDMA cue. Cocaine and DPT substituted for both 
      training drugs, but whereas cocaine was more potent in S(+)-MDMA-trained mice, 
      DPT was more potent in R(-)-MDMA-trained mice. These data suggest that 
      qualitative differences in the discriminative stimulus effects of each 
      stereoisomer of MDMA exist in mice and further our understanding of the complex 
      nature of the interoceptive effects of MDMA.
FAU - Murnane, K S
AU  - Murnane KS
AD  - Emory University, Neuroscience Graduate Program, Atlanta, Georgia, USA.
FAU - Murai, N
AU  - Murai N
FAU - Howell, L L
AU  - Howell LL
FAU - Fantegrossi, W E
AU  - Fantegrossi WE
LA  - eng
GR  - RR020146/RR/NCRR NIH HHS/United States
GR  - P20 RR020146/RR/NCRR NIH HHS/United States
GR  - P51 RR000165/RR/NCRR NIH HHS/United States
GR  - R21 DA020645/DA/NIDA NIH HHS/United States
GR  - DA020645/DA/NIDA NIH HHS/United States
GR  - RR00165/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20090814
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (2,5-dimethoxy-4-n-propylthiophenethylamine)
RN  - 0 (Amphetamines)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Hallucinogens)
RN  - 0 (Phenethylamines)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 0 (Tryptamines)
RN  - 327C7L2BXQ (phenethylamine)
RN  - 61-52-9 (dipropyltryptamine)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Amphetamines/pharmacology
MH  - Animals
MH  - Central Nervous System Stimulants/*pharmacology
MH  - Cocaine/pharmacology
MH  - Conditioning, Operant/drug effects
MH  - Discrimination Learning/drug effects
MH  - Discrimination, Psychological/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Hallucinogens/*pharmacology
MH  - Male
MH  - Mice
MH  - N-Methyl-3,4-methylenedioxyamphetamine/chemistry/*pharmacology
MH  - Phenethylamines/pharmacology
MH  - Selective Serotonin Reuptake Inhibitors/pharmacology
MH  - Stereoisomerism
MH  - Tryptamines/pharmacology
PMC - PMC2775256
EDAT- 2009/08/18 09:00
MHDA- 2009/12/16 06:00
PMCR- 2010/11/01
CRDT- 2009/08/18 09:00
PHST- 2009/08/18 09:00 [entrez]
PHST- 2009/08/18 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2010/11/01 00:00 [pmc-release]
AID - jpet.109.156174 [pii]
AID - 3525473 [pii]
AID - 10.1124/jpet.109.156174 [doi]
PST - ppublish
SO  - J Pharmacol Exp Ther. 2009 Nov;331(2):717-23. doi: 10.1124/jpet.109.156174. Epub 
      2009 Aug 14.