PMID- 19684408
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20101118
IS  - 1660-2110 (Electronic)
IS  - 1660-2110 (Linking)
VI  - 113
IP  - 4
DP  - 2009
TI  - Comparison of long-term outcomes between spousal transplants and other living 
      unrelated donor transplants: single-center experience.
PG  - c241-9
LID - 10.1159/000235248 [doi]
AB  - BACKGROUND/AIMS: The greater use of living unrelated donors (LUDs) as kidney 
      donors is a worldwide trend in the current era of organ shortage, and spouses are 
      an important source of LUDs. This study was to compare the long-term outcomes of 
      spousal donor grafts with other LUD grafts. METHODS: Among 445 LUD grafts, 77 
      were spouses and 368 were other LUDs. The clinical characteristics and long-term 
      survival rates for spousal transplants were compared with those for other LUD 
      transplants, and risk factors affecting graft survival were assessed. RESULTS: 
      Spousal donors had a significantly higher average number of human leukocyte 
      antigen (HLA) mismatches (4.2 vs. 3.4, p < 0.001) and were older (41 vs. 33 
      years, p < 0.001) than LUDs. The 10-year survival rates for spousal donor grafts 
      were 60.6%, similar to those for LUD grafts (58.5%, p = 0.61). The 10-year 
      biopsy-proven acute rejection-free survival rates (85.5 vs. 89.6%, p = 0.45) and 
      patient survival rates were also similar (84.3 vs. 79.6%, p = 0.35). The degree 
      of HLA mismatching, the spousal donor type or donor age did not affect the graft 
      survival. CONCLUSION: Renal transplants from spousal donors show similar 
      long-term outcomes to those from better HLA-matched and younger LUDs.
CI  - (c) 2009 S. Karger AG, Basel.
FAU - Yoon, Hye Eun
AU  - Yoon HE
AD  - Transplantation Research Center, Department of Internal Medicine, Seoul St. 
      Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, 
      Korea.
FAU - Song, Joon Chang
AU  - Song JC
FAU - Hyoung, Bok Jin
AU  - Hyoung BJ
FAU - Hwang, Hyeon Seok
AU  - Hwang HS
FAU - Lee, So Young
AU  - Lee SY
FAU - Jeon, Youn Joo
AU  - Jeon YJ
FAU - Park, Sun Cheol
AU  - Park SC
FAU - Choi, Bum Soon
AU  - Choi BS
FAU - Kim, Yong Soo
AU  - Kim YS
FAU - Moon, In Sung
AU  - Moon IS
FAU - Yang, Chul Woo
AU  - Yang CW
LA  - eng
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20090815
PL  - Switzerland
TA  - Nephron Clin Pract
JT  - Nephron. Clinical practice
JID - 101159763
SB  - IM
MH  - Acute Kidney Injury/*mortality/*rehabilitation
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Kidney Transplantation/classification/*mortality
MH  - Korea/epidemiology
MH  - Living Donors/classification/*statistics & numerical data
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Risk Assessment
MH  - Risk Factors
MH  - Spouses/*statistics & numerical data
MH  - Survival Analysis
MH  - Survival Rate
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2009/08/18 09:00
MHDA- 2010/02/23 06:00
CRDT- 2009/08/18 09:00
PHST- 2009/02/12 00:00 [received]
PHST- 2009/05/01 00:00 [accepted]
PHST- 2009/08/18 09:00 [entrez]
PHST- 2009/08/18 09:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - 000235248 [pii]
AID - 10.1159/000235248 [doi]
PST - ppublish
SO  - Nephron Clin Pract. 2009;113(4):c241-9. doi: 10.1159/000235248. Epub 2009 Aug 15.