PMID- 19685002
OWN - NLM
STAT- MEDLINE
DCOM- 20091203
LR  - 20211020
IS  - 1861-0692 (Electronic)
IS  - 1861-0684 (Linking)
VI  - 98
IP  - 10
DP  - 2009 Oct
TI  - A simple MR algorithm for estimation of myocardial salvage following acute ST 
      segment elevation myocardial infarction.
PG  - 651-6
LID - 10.1007/s00392-009-0051-z [doi]
AB  - PURPOSE: To assess myocardial salvage in acute ST segment elevation myocardial 
      infarction (STEMI) by using contrast-enhanced CMR. METHODS: Forty-four 
      consecutive patients (38 male; mean age 59 +/- 10 years) with a first acute STEMI 
      underwent acute percutaneous coronary intervention with successful restoration of 
      TIMI grade 3 flow. CMR was performed 2 +/- 1 days after reperfusion on a standard 
      1.5 T MR Scanner that included a steady-state free precession cine imaging for LV 
      function and an inversion-recovery fast low angle shot (TR 8 ms, TE 4 ms, FA 25 
      degrees ) sequences for late gadolinium enhancement (LGE) following the injection 
      of 0.2 mmol/kg BW gadodiamide. The myocardium at risk (MR) was approximated by 
      the volume of myocardium exhibiting LGE and/or impaired wall motion. The 
      myocardial salvage index (MSI) was calculated as the volume of the MR minus the 
      volume of LGE divided by the volume of the MR. Reperfusion therapy was rated 
      successful with an ST elevation resolution (STR) > or =70% and was considered 
      inadequate below 70%. RESULTS: Infarct size (LGE) was 17 +/- 13% of LV mass, the 
      mean STR was 53.4 +/- 28.3%, and the MSI was 10.9 +/- 6.2%. There was a good 
      correlation between the MSI and the STR (r = 0.695, P < 0.0001). Thirty patients 
      had an STR below 70%, and 14 patients had an STR greater than 70%. The MSI was 
      greater in patients with a STE resolution of more than 70% (12 +/- 11 vs. 6 +/- 
      3%, P < 0.0001). CONCLUSION: A simple MR algorithm based upon the relationship of 
      functional impairment, which includes myocardial stunning, to the extent of LGE 
      (infarct necrosis) is in accordance with STR as a clinical marker of successful 
      reperfusion in acute myocardial infarction.
FAU - Jensen, Christoph J
AU  - Jensen CJ
AD  - Department of Cardiology and Angiology, Elisabeth Hospital Essen, Klara-Kopp-Weg 
      1, Essen, Germany. c.jensen@contilia.de
FAU - Bleckmann, Dominik
AU  - Bleckmann D
FAU - Eberle, Holger C
AU  - Eberle HC
FAU - Nassenstein, Kai
AU  - Nassenstein K
FAU - Schlosser, Thomas
AU  - Schlosser T
FAU - Sabin, Georg V
AU  - Sabin GV
FAU - Naber, Christoph K
AU  - Naber CK
FAU - Bruder, Oliver
AU  - Bruder O
LA  - eng
PT  - Journal Article
DEP - 20090814
PL  - Germany
TA  - Clin Res Cardiol
JT  - Clinical research in cardiology : official journal of the German Cardiac Society
JID - 101264123
RN  - 0 (Contrast Media)
RN  - 84F6U3J2R6 (gadodiamide)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Aged
MH  - *Algorithms
MH  - *Angioplasty, Balloon, Coronary
MH  - Contrast Media
MH  - *Coronary Circulation
MH  - Electrocardiography
MH  - Feasibility Studies
MH  - Female
MH  - Gadolinium DTPA
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction
MH  - Myocardial Infarction/pathology/physiopathology/*therapy
MH  - Myocardium/*pathology
MH  - Necrosis
MH  - Predictive Value of Tests
MH  - Treatment Outcome
MH  - Ventricular Function, Left
EDAT- 2009/08/18 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/08/18 09:00
PHST- 2009/04/14 00:00 [received]
PHST- 2009/07/07 00:00 [accepted]
PHST- 2009/08/18 09:00 [entrez]
PHST- 2009/08/18 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - 10.1007/s00392-009-0051-z [doi]
PST - ppublish
SO  - Clin Res Cardiol. 2009 Oct;98(10):651-6. doi: 10.1007/s00392-009-0051-z. Epub 
      2009 Aug 14.