PMID- 19685102
OWN - NLM
STAT- MEDLINE
DCOM- 20100202
LR  - 20240130
IS  - 1532-6551 (Electronic)
IS  - 1071-3581 (Linking)
VI  - 16
IP  - 6
DP  - 2009 Nov-Dec
TI  - Myocardial ischemia, carotid, and peripheral arterial disease and their 
      interrelationship in type 2 diabetes patients.
PG  - 878-87
LID - 10.1007/s12350-009-9118-5 [doi]
AB  - BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death in type 2 
      diabetes mellitus (T2DM) patients. We examined the relationship between CVD in 
      different vascular territories. METHODS: T2DM patients without known or suspected 
      CVD (n = 305) referred consecutively to a diabetes clinic for the first time and 
      age-matched nondiabetic reference subjects (n = 40) were screened for myocardial 
      ischemia, carotid, and peripheral arterial disease by means of myocardial 
      perfusion scintigraphy, carotid artery ultrasonography, and peripheral ankle and 
      toe systolic blood pressure measurements. RESULTS: In the T2DM patients, the 
      prevalence of myocardial ischemia, carotid, and peripheral arterial disease was 
      30%, 42%, and 15%, respectively, almost three times higher than in the reference 
      subjects (P = 0.007, P = 0.001, and P = 0.09, respectively). T2DM patients with 
      myocardial ischemia, carotid, or peripheral arterial disease had a significantly 
      increased risk of CVD in other vascular territories as well (OR: 1.99, 2.09, and 
      3.09, respectively). However, 40%, 52%, and 22% of the T2DM patients with 
      myocardial ischemia, carotid, or peripheral arterial disease demonstrated 
      exclusively this particular type of CVD manifestation. CONCLUSIONS: In T2DM 
      patients, signs of CVD in one vascular territory carry a significantly increased 
      risk of CVD in other territories, although many patients only presented one 
      manifestation.
FAU - Poulsen, Mikael K
AU  - Poulsen MK
AD  - Department of Endocrinology, Odense University Hospital, Klovervaenget 6, 5th 
      Floor, 5000, Odense C, Denmark. doc_mkp@hotmail.com
FAU - Henriksen, Jan Erik
AU  - Henriksen JE
FAU - Dahl, Jordi
AU  - Dahl J
FAU - Johansen, Allan
AU  - Johansen A
FAU - Moller, Jacob E
AU  - Moller JE
FAU - Gerke, Oke
AU  - Gerke O
FAU - Vach, Werner
AU  - Vach W
FAU - Haghfelt, Torben
AU  - Haghfelt T
FAU - Beck-Nielsen, Henning
AU  - Beck-Nielsen H
FAU - Hoilund-Carlsen, Poul Flemming
AU  - Hoilund-Carlsen PF
LA  - eng
SI  - ClinicalTrials.gov/NCT00298844
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090814
PL  - United States
TA  - J Nucl Cardiol
JT  - Journal of nuclear cardiology : official publication of the American Society of 
      Nuclear Cardiology
JID - 9423534
SB  - IM
MH  - Carotid Artery Diseases/*diagnostic imaging/*epidemiology
MH  - Comorbidity
MH  - Denmark/epidemiology
MH  - Diabetes Mellitus, Type 2/*diagnostic imaging/*epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*diagnostic imaging/*epidemiology
MH  - Myocardial Perfusion Imaging/statistics & numerical data
MH  - Peripheral Vascular Diseases/*diagnostic imaging/*epidemiology
MH  - Prevalence
MH  - Risk Assessment/methods
MH  - Risk Factors
EDAT- 2009/08/18 09:00
MHDA- 2010/02/03 06:00
CRDT- 2009/08/18 09:00
PHST- 2009/04/05 00:00 [received]
PHST- 2009/07/01 00:00 [accepted]
PHST- 2009/06/30 00:00 [revised]
PHST- 2009/08/18 09:00 [entrez]
PHST- 2009/08/18 09:00 [pubmed]
PHST- 2010/02/03 06:00 [medline]
AID - S1071-3581(23)03517-1 [pii]
AID - 10.1007/s12350-009-9118-5 [doi]
PST - ppublish
SO  - J Nucl Cardiol. 2009 Nov-Dec;16(6):878-87. doi: 10.1007/s12350-009-9118-5. Epub 
      2009 Aug 14.