PMID- 19685554
OWN - NLM
STAT- MEDLINE
DCOM- 20100126
LR  - 20171116
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Linking)
VI  - 25
IP  - 7
DP  - 2009 Oct
TI  - Fasting hyperinsulinemia associates with increased sub-clinical inflammation in 
      first-degree relatives normal glucose tolerant women independently of the 
      metabolic syndrome.
PG  - 639-46
LID - 10.1002/dmrr.1003 [doi]
AB  - BACKGROUND: To evaluate the influence of gender on the relationship between 
      inflammation and hyperinsulinemia in first-degree relatives of type 2 diabetic 
      patients independently of metabolic syndrome. METHODS: Study group consisted in 
      217 first-degree relatives with normal glucose tolerance after an oral glucose 
      tolerance test. A logistic analysis, adjusted for age, sex and all the components 
      of the metabolic syndrome, was used to determine the relationship between 
      interleukin-6 (IL-6) and leptin and tertiles of fasting insulin, and to take into 
      account the influence of gender. RESULTS: In the whole cohort, IL-6 and leptin 
      were significantly higher and adiponectin significantly lower in the III tertile 
      when corrected for age, body mass index (BMI) and metabolic syndrome components. 
      In women, but not in men, IL-6 and leptin remained significantly higher when 
      corrected for metabolic syndrome. In the whole cohort and in women, univariate 
      correlations between IL-6 concentrations and the parameters under evaluation 
      showed that IL-6 and leptin were positively correlated with age, BMI, waist, 
      systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting glucose, 
      fasting insulin, Delta AUC insulin area, triglyceride (TG), free fatty acids 
      (FFA) and monocyte chemoattractant protein-1 (MCP-1) and inversely correlated 
      with HDL cholesterol (HDL-C) and adiponectin. In women a forward stepwise linear 
      regression analysis in a model including age, BMI, features of metabolic 
      syndrome, fasting insulin, Delta AUC insulin and insulin sensitivity index (ISI) 
      index revealed that only IL-6 and leptin were independently associated with 
      fasting insulin levels. CONCLUSIONS: In first-degree relatives normal glucose 
      tolerant women, fasting hyperinsulinemia, independently of the presence of 
      metabolic syndrome, is associated with elevated IL-6 and leptin levels, 
      suggesting an increased cardiovascular risk.
CI  - (c) 2009 John Wiley & Sons, Ltd.
FAU - Setola, Emanuela
AU  - Setola E
AD  - Cardio-Metabolic and Clinical Trials Unit and Cardiodiabetes & Core-Lab, 
      Metabolic and Cardiovascular Science Division and Internal Medicine Department, 
      San Raffaele Scientific Institute, Milan, Italy.
FAU - Monti, Lucilla D
AU  - Monti LD
FAU - Lucotti, Pietro
AU  - Lucotti P
FAU - Galluccio, Elena
AU  - Galluccio E
FAU - Oldani, Matteo
AU  - Oldani M
FAU - Bosi, Emanuele
AU  - Bosi E
FAU - Piatti, PierMarco
AU  - Piatti P
LA  - eng
PT  - Journal Article
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
RN  - 0 (Adiponectin)
RN  - 0 (Insulin)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Adiponectin/blood
MH  - Adult
MH  - Body Mass Index
MH  - Cardiovascular Diseases/physiopathology
MH  - Diabetes Mellitus, Type 2/blood/*genetics
MH  - Family
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Hyperinsulinism/blood/*complications/genetics
MH  - Inflammation/blood/*complications/genetics
MH  - Insulin/blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Metabolic Syndrome/blood/*complications
MH  - Middle Aged
MH  - Regression Analysis
MH  - Risk Factors
MH  - Sex Characteristics
EDAT- 2009/08/18 09:00
MHDA- 2010/01/27 06:00
CRDT- 2009/08/18 09:00
PHST- 2009/08/18 09:00 [entrez]
PHST- 2009/08/18 09:00 [pubmed]
PHST- 2010/01/27 06:00 [medline]
AID - 10.1002/dmrr.1003 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2009 Oct;25(7):639-46. doi: 10.1002/dmrr.1003.