PMID- 1968616
OWN - NLM
STAT- MEDLINE
DCOM- 19900403
LR  - 20041117
IS  - 0028-4793 (Print)
IS  - 0028-4793 (Linking)
VI  - 322
IP  - 11
DP  - 1990 Mar 15
TI  - Gastrinomas in the duodenums of patients with multiple endocrine neoplasia type 1 
      and the Zollinger-Ellison syndrome.
PG  - 723-7
AB  - In patients with multiple endocrine neoplasia type 1 (MEN-1), gastrinomas are 
      common and thought to occur predominantly in the pancreas. We describe eight 
      patients with MEN-1 and hypergastrinemia (seven with the Zollinger-Ellison 
      syndrome) in whom we searched for neuroendocrine tumors in the pancreas and 
      duodenum. Tumors were found in the proximal duodenum in all eight patients: 
      solitary tumors (diameter, 6 to 20 mm) in three patients and multiple microtumors 
      (diameter, 2 to 6 mm) in the other five. Paraduodenal lymph-node metastases were 
      detected in four patients. Immunocytochemical analysis revealed the presence of 
      gastrin in all the duodenal tumors and in their lymph-node metastases. In 
      contrast, no immunoreactivity for gastrin was present in the endocrine tumors 
      found in the seven pancreatic specimens available for study, except for one tumor 
      with scattered gastrin-positive cells. In four of the six patients whose duodenal 
      gastrinomas were removed, serum gastrin levels returned to normal; in the other 
      two patients gastrin concentrations decreased toward normal. We conclude that in 
      patients with MEN-1 and the Zollinger-Ellison syndrome, gastrinomas occur in the 
      duodenum, but the tumors may be so small that they escape detection.
FAU - Pipeleers-Marichal, M
AU  - Pipeleers-Marichal M
AD  - Department of Pathology, Academic Hospital, Vrije Universiteit Brussel, Belgium.
FAU - Somers, G
AU  - Somers G
FAU - Willems, G
AU  - Willems G
FAU - Foulis, A
AU  - Foulis A
FAU - Imrie, C
AU  - Imrie C
FAU - Bishop, A E
AU  - Bishop AE
FAU - Polak, J M
AU  - Polak JM
FAU - Hacki, W H
AU  - Hacki WH
FAU - Stamm, B
AU  - Stamm B
FAU - Heitz, P U
AU  - Heitz PU
AU  - et al.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
RN  - 0 (Gastrins)
SB  - IM
CIN - N Engl J Med. 1990 Aug 2;323(5):349-50. PMID: 1973264
MH  - Adult
MH  - Aged
MH  - Duodenal Neoplasms/*pathology
MH  - Female
MH  - Gastrinoma/*pathology
MH  - Gastrins/blood
MH  - Humans
MH  - Immunohistochemistry
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia/*pathology
MH  - Pancreatic Neoplasms/pathology
MH  - Zollinger-Ellison Syndrome/*pathology
EDAT- 1990/03/15 00:00
MHDA- 1990/03/15 00:01
CRDT- 1990/03/15 00:00
PHST- 1990/03/15 00:00 [pubmed]
PHST- 1990/03/15 00:01 [medline]
PHST- 1990/03/15 00:00 [entrez]
AID - 10.1056/NEJM199003153221103 [doi]
PST - ppublish
SO  - N Engl J Med. 1990 Mar 15;322(11):723-7. doi: 10.1056/NEJM199003153221103.