PMID- 19686433
OWN - NLM
STAT- MEDLINE
DCOM- 20091027
LR  - 20090818
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 30
IP  - 3
DP  - 2009 Aug
TI  - Afferent-induced facilitation of primary motor cortex excitability in the region 
      controlling hand muscles in humans.
PG  - 439-48
LID - 10.1111/j.1460-9568.2009.06815.x [doi]
AB  - Sensory inputs from cutaneous and limb receptors are known to influence motor 
      cortex network excitability. Although most recent studies have focused on the 
      inhibitory influences of afferent inputs on arm motor responses evoked by 
      transcranial magnetic stimulation (TMS), facilitatory effects are rarely 
      considered. In the present work, we sought to establish how proprioceptive 
      sensory inputs modulate the excitability of the primary motor cortex region 
      controlling certain hand and wrist muscles. Suprathreshold TMS pulses were 
      preceded either by median nerve stimulation (MNS) or index finger stimulation 
      with interstimulus intervals (ISIs) ranging from 20 to 200 ms (with particular 
      focus on 40-80 ms). Motor-evoked potentials recorded in the abductor pollicis 
      brevis (APB), first dorsalis interosseus and extensor carpi radialis muscles were 
      strongly facilitated (by up to 150%) by MNS with ISIs of around 60 ms, whereas 
      digit stimulation had only a weak effect. When MNS was delivered at the interval 
      that evoked the optimal facilitatory effect, the H-reflex amplitude remained 
      unchanged and APB motor responses evoked with transcranial electric stimulation 
      were not increased as compared with TMS. Afferent-induced facilitation and 
      short-latency intracortical inhibition (SICI) and intracortical facilitation 
      (ICF) mechanisms are likely to interact in cortical circuits, as suggested by the 
      strong facilitation observed when MNS was delivered concurrently with ICF and the 
      reduction of SICI following MNS. We conclude that afferent-induced facilitation 
      is a mechanism which probably involves muscle spindle afferents and should be 
      considered when studying sensorimotor integration mechanisms in healthy and 
      disease situations.
FAU - Devanne, H
AU  - Devanne H
AD  - Neurophysiologie Clinique, CHRU Lille, Hopital Roger Salengro, Lille Cedex, 
      France. h-devanne@chru-lille.fr
FAU - Degardin, A
AU  - Degardin A
FAU - Tyvaert, L
AU  - Tyvaert L
FAU - Bocquillon, P
AU  - Bocquillon P
FAU - Houdayer, E
AU  - Houdayer E
FAU - Manceaux, A
AU  - Manceaux A
FAU - Derambure, P
AU  - Derambure P
FAU - Cassim, F
AU  - Cassim F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090707
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
SB  - IM
MH  - Adult
MH  - Afferent Pathways/*physiology
MH  - Electric Stimulation
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - H-Reflex/physiology
MH  - Hand/*innervation/physiology
MH  - Humans
MH  - Male
MH  - Median Nerve/physiology
MH  - Motor Cortex/*physiology
MH  - Muscle, Skeletal/*innervation/physiology
MH  - Transcranial Magnetic Stimulation
EDAT- 2009/08/19 09:00
MHDA- 2009/10/29 06:00
CRDT- 2009/08/19 09:00
PHST- 2009/08/19 09:00 [entrez]
PHST- 2009/08/19 09:00 [pubmed]
PHST- 2009/10/29 06:00 [medline]
AID - EJN6815 [pii]
AID - 10.1111/j.1460-9568.2009.06815.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2009 Aug;30(3):439-48. doi: 10.1111/j.1460-9568.2009.06815.x. 
      Epub 2009 Jul 7.