PMID- 19688326
OWN - NLM
STAT- MEDLINE
DCOM- 20100427
LR  - 20161026
IS  - 0070-217X (Print)
IS  - 0070-217X (Linking)
VI  - 336
DP  - 2009
TI  - Toll-like receptors in bacterial meningitis.
PG  - 15-40
LID - 10.1007/978-3-642-00549-7_2 [doi]
AB  - Bacterial meningitis is still an important infectious disease with a high 
      morbidity and mortality rate. Bacterial infection of the cerebrospinal fluid 
      (CSF) space causes a powerful inflammatory reaction that is largely responsibly 
      for meningitis-induced tissue damage and adverse outcome of the disease. In a 
      landmark series of experiments in the mid-1980s, cell wall components including 
      lipooligosaccharides and lipoteichoic acid were indicated to be the key bacterial 
      elements that can trigger the host inflammatory response in the CSF. Ten years 
      ago, the discovery of Toll-like receptor proteins (TLRs) that allow the detection 
      of microbial components and initiate the host immune response opened up new 
      horizons in research on the pathophysiology of meningitis. Cell culture 
      approaches provided the first evidence for a crucial role of TLRs in sensing 
      meningeal pathogens including Streptococcus pneumoniae, Neisseria meningitidis, 
      Streptococcus agalactiae, and Listeria monocytogenes. Subsequently, studies in 
      mice with single or combined deficiencies in TLRs demonstrated that TLR 
      activation is a key event in meningeal inflammation and, even more interestingly, 
      a pivotal factor for meningitis-associated tissue damage. A detailed 
      understanding of the mechanisms of host-pathogen interactions in the CSF space 
      may generate new opportunities for specific treatment strategies for bacterial 
      meningitis.
FAU - Koedel, Uwe
AU  - Koedel U
AD  - Clinic of the Ludwig-Maximilians, Department of Neurology, University of Munich, 
      Marchioninistr 15, Munich 81377, Germany. Uwe.Koedel@med.uni-muenchen.de
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Germany
TA  - Curr Top Microbiol Immunol
JT  - Current topics in microbiology and immunology
JID - 0110513
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - Host-Pathogen Interactions
MH  - Humans
MH  - Listeria monocytogenes
MH  - Meningitis, Bacterial/*immunology/microbiology
MH  - Neisseria meningitidis
MH  - Streptococcus agalactiae
MH  - Streptococcus pneumoniae
MH  - Toll-Like Receptors/*immunology
RF  - 119
EDAT- 2009/08/19 09:00
MHDA- 2010/04/28 06:00
CRDT- 2009/08/19 09:00
PHST- 2009/08/19 09:00 [entrez]
PHST- 2009/08/19 09:00 [pubmed]
PHST- 2010/04/28 06:00 [medline]
AID - 10.1007/978-3-642-00549-7_2 [doi]
PST - ppublish
SO  - Curr Top Microbiol Immunol. 2009;336:15-40. doi: 10.1007/978-3-642-00549-7_2.