PMID- 19689066
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20131121
IS  - 1000-8020 (Print)
IS  - 1000-8020 (Linking)
VI  - 38
IP  - 4
DP  - 2009 Jul
TI  - [Study on the relationship between FABP2 Ala54Thr polymorphism and the risk of 
      non-alcoholic fatty liver diseases].
PG  - 401-4
AB  - OBJECTIVE: To explore the relationship between FABP2 Ala54Thr polymorphism and 
      the risk of non-alcoholic fatty liver diseases (NFLD). METHODS: A hospital-based 
      case-control study was conducted and polymerase chain reaction-restriction 
      fragment length polymorphism (PCR-RFLP) method was used to detect FABP2 Ala54Thr 
      genotypes. The cases and controls were interviewed by using the same 
      questionnaire. RESULTS: The genotype frequencies of Ala54Ala, Ala54Thr and 
      Thr54Thr were 39.7%, 46.6% and 13.7% in cases, and 48.5%, 43.1% and 8.4% in 
      controls. The Thr allele frequency in cases (36.97%) was higher than that in the 
      controls (29.94%)(P = 0.01). Multiple logistic regression results showed that 
      after adjusting other confound factors, the Thr54 Thr genotype was the 
      independent risk factor of NFLD (OR = 1.97, 95% CI: 1.18-3.35). CONCLUSION: FABP2 
      Thr54Thr genotype might increase the risk of NFLD development.
FAU - Peng, Xian'e
AU  - Peng X
AD  - School of Public Health, Fujian Medical University, Fuzhou 350004, China. 
      fmuxe@163.com
FAU - Zhang, Ling
AU  - Zhang L
FAU - Wang, Qingqing
AU  - Wang Q
FAU - Cui, Xu
AU  - Cui X
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Wei Sheng Yan Jiu
JT  - Wei sheng yan jiu = Journal of hygiene research
JID - 9426367
RN  - 0 (FABP2 protein, human)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 2ZD004190S (Threonine)
RN  - OF5P57N2ZX (Alanine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alanine/genetics
MH  - Amino Acid Substitution
MH  - Case-Control Studies
MH  - Fatty Acid-Binding Proteins/*genetics
MH  - Fatty Liver/etiology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mutation
MH  - Polymerase Chain Reaction/methods
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - Risk Factors
MH  - Threonine/genetics
MH  - Young Adult
EDAT- 2009/08/20 09:00
MHDA- 2010/12/14 06:00
CRDT- 2009/08/20 09:00
PHST- 2009/08/20 09:00 [entrez]
PHST- 2009/08/20 09:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Wei Sheng Yan Jiu. 2009 Jul;38(4):401-4.