PMID- 19689302
OWN - NLM
STAT- MEDLINE
DCOM- 20091203
LR  - 20240418
IS  - 1875-5666 (Electronic)
IS  - 1566-5240 (Print)
IS  - 1566-5240 (Linking)
VI  - 9
IP  - 6
DP  - 2009 Aug
TI  - HLA associations with nasopharyngeal carcinoma.
PG  - 751-65
AB  - Several associations have been described between the frequency of human leukocyte 
      antigen (HLA) class I genes in certain populations and the risk of developing 
      nasopharyngeal carcinoma (NPC). Associations between ethnic background and 
      geographic distribution, and relative disease incidence have been reported. 
      Populations in geographical areas at higher risk of developing NPC display HLA 
      distribution patterns different and sometimes opposite from areas of low 
      incidence, whereas populations in areas with intermediate incidence display a 
      totally independent pattern. Two main reasons may explain this association 
      between HLA phenotype distribution and the risk of developing NPC in various 
      populations. First, given the fact that expression of Epstein-Barr Virus (EBV) 
      proteins by cancer cells is tightly linked with NPC development, HLA may 
      influence the development of NPC by modulating the expression of EBV proteins. 
      This explanation is, however, based primarily on theoretical assumptions given 
      that no clear definition of HLA binding pattern of EBV epitopes has been directly 
      shown to significantly alter the recognition of EBV proteins and the risk of 
      developing the disease. Alternatively, HLA may represent a genetic marker 
      flagging the presence of a NPC predisposition locus in close linkage 
      disequilibrium with the HLA class I region. A critical review of known HLA 
      associations in various geographical areas and their interpretation will be 
      presented in this review.
FAU - Li, Xin
AU  - Li X
AD  - Infectious Disease and Immunogenetics Section, Department of Transfusion 
      Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland 
      20892, USA. xinli268@gmail.com
FAU - Fasano, Ross
AU  - Fasano R
FAU - Wang, Ena
AU  - Wang E
FAU - Yao, Kai-Tai
AU  - Yao KT
FAU - Marincola, Francesco M
AU  - Marincola FM
LA  - eng
GR  - ZIA CL002118/ImNIH/Intramural NIH HHS/United States
GR  - ZIA CL002118-04/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Curr Mol Med
JT  - Current molecular medicine
JID - 101093076
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Geography
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Nasopharyngeal Neoplasms/epidemiology/genetics/*immunology
MH  - Prevalence
MH  - Risk Factors
PMC - PMC3407690
MID - NIHMS394810
EDAT- 2009/08/20 09:00
MHDA- 2009/12/16 06:00
PMCR- 2012/07/29
CRDT- 2009/08/20 09:00
PHST- 2009/08/20 09:00 [entrez]
PHST- 2009/08/20 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2012/07/29 00:00 [pmc-release]
AID - 10.2174/156652409788970698 [doi]
PST - ppublish
SO  - Curr Mol Med. 2009 Aug;9(6):751-65. doi: 10.2174/156652409788970698.