PMID- 19689819
OWN - NLM
STAT- MEDLINE
DCOM- 20091103
LR  - 20211020
IS  - 1743-422X (Electronic)
IS  - 1743-422X (Linking)
VI  - 6
DP  - 2009 Aug 19
TI  - y Human herpesvirus 6 envelope components enriched in lipid rafts: evidence for 
      virion-associated lipid rafts.
PG  - 127
LID - 10.1186/1743-422X-6-127 [doi]
AB  - In general, enveloped viruses are highly dependent on their lipid envelope for 
      entry into host cells. Here, we demonstrated that during the course of virus 
      maturation, a significant proportion of human herpesvirus 6 (HHV-6) envelope 
      proteins were selectively concentrated in the detergent-resistant 
      glycosphingolipid- and cholesterol-rich membranes (rafts) in HHV-6-infected 
      cells. In addition, the ganglioside GM1, which is known to partition 
      preferentially into lipid rafts, was detected in purified virions, along with 
      viral envelope glycoproteins, gH, gL, gB, gQ1, gQ2 and gO indicating that at 
      least one raft component was included in the viral particle during the assembly 
      process.
FAU - Kawabata, Akiko
AU  - Kawabata A
AD  - Division of Biomedical Research, National Institute of Biomedical Innovation, 
      Ibaraki, Osaka, Japan. akawabata@nibio.go.jp
FAU - Tang, Huamin
AU  - Tang H
FAU - Huang, Honglan
AU  - Huang H
FAU - Yamanishi, Koichi
AU  - Yamanishi K
FAU - Mori, Yasuko
AU  - Mori Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090819
PL  - England
TA  - Virol J
JT  - Virology journal
JID - 101231645
RN  - 0 (Membrane Lipids)
RN  - 0 (Viral Envelope Proteins)
SB  - IM
MH  - Cell Line
MH  - Cell Membrane/chemistry/metabolism/virology
MH  - Herpesvirus 6, Human/chemistry/*metabolism
MH  - Humans
MH  - Membrane Lipids/analysis/*metabolism
MH  - Roseolovirus Infections/*metabolism/virology
MH  - Viral Envelope Proteins/analysis/*metabolism
MH  - Virion/chemistry/*metabolism
PMC - PMC2743664
EDAT- 2009/08/20 09:00
MHDA- 2009/11/05 06:00
PMCR- 2009/08/19
CRDT- 2009/08/20 09:00
PHST- 2009/06/01 00:00 [received]
PHST- 2009/08/19 00:00 [accepted]
PHST- 2009/08/20 09:00 [entrez]
PHST- 2009/08/20 09:00 [pubmed]
PHST- 2009/11/05 06:00 [medline]
PHST- 2009/08/19 00:00 [pmc-release]
AID - 1743-422X-6-127 [pii]
AID - 10.1186/1743-422X-6-127 [doi]
PST - epublish
SO  - Virol J. 2009 Aug 19;6:127. doi: 10.1186/1743-422X-6-127.