PMID- 19694821
OWN - NLM
STAT- MEDLINE
DCOM- 20091113
LR  - 20090821
IS  - 1365-2559 (Electronic)
IS  - 0309-0167 (Linking)
VI  - 55
IP  - 2
DP  - 2009 Aug
TI  - Immunohistochemical and molecular genetic profiling of acquired cystic 
      disease-associated renal cell carcinoma.
PG  - 145-53
LID - 10.1111/j.1365-2559.2009.03361.x [doi]
AB  - AIMS: Acquired cystic disease-associated renal cell carcinoma (ACD-associated 
      RCC) is a unique neoplasm that specifically develops in the background of 
      acquired cystic disease of the kidney. The aim was to analyse nine ACD-associated 
      RCCs from three patients to determine their immunohistochemical and molecular 
      characteristics using immunohistochemistry, comparative genomic hybridization 
      (CGH) and fluorescence in situ hybridization (FISH). METHODS AND RESULTS: 
      ACD-associated RCC preferentially expressed proximal nephron phenotype (CD10+ 
      /RCC marker+/alpha-methylacyl-CoA racemase+ /glutathione S-transferase-alpha+ 
      /BerEP4+ /cytokeratin 7- /E-cadherin- /high-molecular-weight cytokeratin- 
      /MOC31-). CGH combined with FISH demonstrated non-random chromosomal gains 
      clustering on chromosomes 3 (8/9), 7 (6/9), 16 (7/9), 17 (4/9) and Y (5/9). 
      Chromosomal losses were uncommon. The chromosomal aberrations in all multifocal 
      tumours were not identical for the same kidney or for the same patient, 
      indicating a 'field effect' that induces multiple independent clones. 
      CONCLUSIONS: Although the genetic profiles of ACD-associated RCC showed some 
      similarity to those of papillary RCC, ACD-associated RCC distinctly revealed 
      frequent gains on chromosomes 3 and Y. ACD-associated RCC is characterized not 
      only by its particular clinical setting and histology, but also by its unique 
      immunohistochemical and molecular genetic profiles.
FAU - Pan, Chin-Chen
AU  - Pan CC
AD  - Department of Pathology, Taipei Veterans General Hospital and National Yang-Ming 
      University, No. 201, Shi-Pai Rd, Sec. 2, Taipei 11217, Taiwan. 
      ccpan@vghtpe.gov.tw
FAU - Chen, Yann-Jang
AU  - Chen YJ
FAU - Chang, Liang-Che
AU  - Chang LC
FAU - Chang, Yen-Hwa
AU  - Chang YH
FAU - Ho, Donald M-T
AU  - Ho DM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Histopathology
JT  - Histopathology
JID - 7704136
SB  - IM
MH  - Carcinoma, Renal Cell/*genetics
MH  - *Comparative Genomic Hybridization
MH  - Humans
MH  - *Immunohistochemistry
MH  - *In Situ Hybridization, Fluorescence
MH  - Kidney Diseases, Cystic/*genetics
EDAT- 2009/08/22 09:00
MHDA- 2009/11/17 06:00
CRDT- 2009/08/22 09:00
PHST- 2009/08/22 09:00 [entrez]
PHST- 2009/08/22 09:00 [pubmed]
PHST- 2009/11/17 06:00 [medline]
AID - HIS3361 [pii]
AID - 10.1111/j.1365-2559.2009.03361.x [doi]
PST - ppublish
SO  - Histopathology. 2009 Aug;55(2):145-53. doi: 10.1111/j.1365-2559.2009.03361.x.