PMID- 19695047
OWN - NLM
STAT- MEDLINE
DCOM- 20091105
LR  - 20090821
IS  - 1754-9485 (Electronic)
IS  - 1754-9477 (Linking)
VI  - 53
IP  - 4
DP  - 2009 Aug
TI  - Conformal external beam radiotherapy in the treatment of anal canal carcinoma: a 
      retrospective study of a genital organ sparing technique.
PG  - 396-404
LID - 10.1111/j.1754-9485.2009.02083.x [doi]
AB  - To investigate and compare the dosimetric distribution of a conventional 
      radiotherapy (CRT) technique and a genital organ sparing three-dimensional 
      conformal radiotherapy (3DCRT) technique for the treatment of anal canal cancer. 
      Twenty-four patients with anal canal cancer treated between January 2002 and 
      December 2006 were investigated. Each patient was retrospectively planned with 
      the CRT and 3DCRT techniques using the Eclipse planning system (version 7.3, 
      Varian Medical Systems, Palo Alto, CA, USA). Planning target volumes (PTVs) and 
      surrounding organs at risk were contoured. Organs at risk included the bladder, 
      bowel, femoral head and neck, and external genitalia. The two planning approaches 
      were compared using dose volume histograms. Dose volume histograms of the PTV 
      pelvis and PTV inguinal showed comparable PTV coverage between the two 
      techniques. The mean percentage volumes of the PTV pelvis and PTV inguinal 
      receiving at least 95% of the prescribed dose was greater than 99% and 91.5%, 
      respectively. Dose volume histograms of the external genitalia demonstrated that 
      they were well spared by the 3DCRT technique with mean doses of 28.30 and 13.17 
      Gy for the CRT and 3DCRT techniques, respectively. The percentage volume of bowel 
      and bladder receiving 35 Gy or less was reduced with the 3DCRT technique. The 
      femoral head and neck doses were comparable between the two techniques, with 
      average maximum doses recorded of 40.60 and 40.69 Gy. The results of this study 
      demonstrate that the 3DCRT technique achieves significant sparing of surrounding 
      organs at risk, particularly the external genitalia. This organ at risk sparing 
      was accomplished while achieving comparable PTV coverage with a CRT technique.
FAU - Bui, T
AU  - Bui T
AD  - Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane, 
      Queensland, Australia.
FAU - Harvey, J
AU  - Harvey J
FAU - Brown, E
AU  - Brown E
FAU - Scott, M
AU  - Scott M
FAU - Haines, T
AU  - Haines T
FAU - Davidson, K
AU  - Davidson K
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Med Imaging Radiat Oncol
JT  - Journal of medical imaging and radiation oncology
JID - 101469340
SB  - IM
MH  - Adult
MH  - Aged, 80 and over
MH  - Anus Neoplasms/*radiotherapy
MH  - Female
MH  - Genitalia/radiation effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Radiation Injuries/etiology/*prevention & control
MH  - Radiation Protection/*methods
MH  - Radiotherapy, Conformal/adverse effects/*methods
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2009/08/22 09:00
MHDA- 2009/11/06 06:00
CRDT- 2009/08/22 09:00
PHST- 2009/08/22 09:00 [entrez]
PHST- 2009/08/22 09:00 [pubmed]
PHST- 2009/11/06 06:00 [medline]
AID - ARA2083 [pii]
AID - 10.1111/j.1754-9485.2009.02083.x [doi]
PST - ppublish
SO  - J Med Imaging Radiat Oncol. 2009 Aug;53(4):396-404. doi: 
      10.1111/j.1754-9485.2009.02083.x.