PMID- 19695831
OWN - NLM
STAT- MEDLINE
DCOM- 20100714
LR  - 20100215
IS  - 1873-1244 (Electronic)
IS  - 0899-9007 (Linking)
VI  - 26
IP  - 3
DP  - 2010 Mar
TI  - Elevated serum tumor necrosis factor-alpha and soluble tumor necrosis factor 
      receptors correlate with aberrant energy metabolism in liver cirrhosis.
PG  - 269-75
LID - 10.1016/j.nut.2009.04.016 [doi]
AB  - OBJECTIVE: Protein-energy malnutrition is frequently observed in patients with 
      liver cirrhosis and is associated with their poor prognosis. Tumor necrosis 
      factor-alpha (TNF-alpha) is elevated in those patients and may contribute to the 
      alterations of energy metabolism. Our aim was to characterize the aberrant energy 
      metabolism in cirrhotic patients with regard to TNF-alpha. METHODS: Twenty-four 
      patients (mean age 65 +/- 6 y) with viral liver cirrhosis who did not have 
      hepatocellular carcinoma or acute infections were studied. Twelve healthy 
      volunteers were recruited after matching for age, gender, and body mass index 
      with the patients and served as controls (59 +/- 8 y). Serum levels of TNF-alpha, 
      soluble 55-kDa TNF receptor (sTNF-R55), soluble 75-kDa TNF receptor (sTNF-R75), 
      and leptin were determined by immunoassay. Substrate oxidation rates of 
      carbohydrate and fat were estimated by indirect calorimetry after overnight 
      bedrest and fasting. RESULTS: In cirrhotic patients, serum levels of TNF-alpha, 
      sTNF-R55, and sTNF-R75 were significantly higher than those in the controls and 
      correlated with the increasing grade of disease severity as defined by Child-Pugh 
      classification. Serum leptin concentration was not different between cirrhotics 
      and controls but correlated with their body mass index. The decrease in substrate 
      oxidation rate of carbohydrate and the increase in substrate oxidation rate of 
      fat significantly correlated with serum TNF-alpha, sTNF-R55, and sTNF-R75 
      concentrations. CONCLUSION: Tumor necrosis factor-alpha might be associated with 
      the aberrant energy metabolism in patients with liver cirrhosis.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Shiraki, Makoto
AU  - Shiraki M
AD  - Department of Internal Medicine, Gifu University School of Medicine, Yanagido, 
      Gifu, Japan. mshiraki-gif@umin.ac.jp
FAU - Terakura, Yoichi
AU  - Terakura Y
FAU - Iwasa, Junpei
AU  - Iwasa J
FAU - Shimizu, Masahito
AU  - Shimizu M
FAU - Miwa, Yoshiyuki
AU  - Miwa Y
FAU - Murakami, Nobuo
AU  - Murakami N
FAU - Nagaki, Masahito
AU  - Nagaki M
FAU - Moriwaki, Hisataka
AU  - Moriwaki H
LA  - eng
PT  - Journal Article
DEP - 20090819
PL  - United States
TA  - Nutrition
JT  - Nutrition (Burbank, Los Angeles County, Calif.)
JID - 8802712
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Leptin)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Aged
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Dietary Carbohydrates/*metabolism
MH  - Dietary Fats/*metabolism
MH  - *Energy Metabolism
MH  - Female
MH  - Humans
MH  - Leptin/blood
MH  - Liver Cirrhosis/complications/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Oxidation-Reduction
MH  - Protein-Energy Malnutrition/etiology/*metabolism
MH  - Receptors, Tumor Necrosis Factor/*blood
MH  - Severity of Illness Index
MH  - Tumor Necrosis Factor-alpha/*blood
EDAT- 2009/08/22 09:00
MHDA- 2010/07/16 06:00
CRDT- 2009/08/22 09:00
PHST- 2008/11/04 00:00 [received]
PHST- 2009/04/22 00:00 [revised]
PHST- 2009/04/22 00:00 [accepted]
PHST- 2009/08/22 09:00 [entrez]
PHST- 2009/08/22 09:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - S0899-9007(09)00199-3 [pii]
AID - 10.1016/j.nut.2009.04.016 [doi]
PST - ppublish
SO  - Nutrition. 2010 Mar;26(3):269-75. doi: 10.1016/j.nut.2009.04.016. Epub 2009 Aug 
      19.