PMID- 19696228
OWN - NLM
STAT- MEDLINE
DCOM- 20090923
LR  - 20161125
IS  - 1476-6256 (Electronic)
IS  - 0002-9262 (Linking)
VI  - 170
IP  - 6
DP  - 2009 Sep 15
TI  - Association between heme oxygenase-1 gene promoter polymorphisms and type 2 
      diabetes in a Chinese population.
PG  - 747-56
LID - 10.1093/aje/kwp196 [doi]
AB  - The authors aimed to determine whether 2 functional polymorphisms in the heme 
      oxygenase-1 (HO-1) gene promoter are associated with type 2 diabetes mellitus 
      (T2DM). A Chinese case-control study involving 1,103 newly diagnosed T2DM 
      patients, 371 patients with impaired glucose regulation (IGR), and 1,615 controls 
      was performed (December 2004-December 2007). A (GT)(n) microsatellite 
      polymorphism and a single nucleotide polymorphism, T(-413)A, were genotyped, and 
      their functional relevance was evaluated by examining the level of HO-1 protein 
      expression. For the (GT)(n) microsatellite polymorphism, genotypes with the L 
      (GT)(n) allele (>or=25 GT repeats) were associated with increased odds of IGR or 
      T2DM compared with the S/S genotype (<25 GT repeats) (S/L genotype: odds ratio 
      (OR) = 1.35, P = 0.048; L/L genotype: OR = 1.65, P = 0.006). Subsequent haplotype 
      analysis showed that haplotype TL contributed to increased odds of IGR or T2DM 
      compared with haplotype TS (OR = 1.56, P = 0.003). In functional analyses, HO-1 
      expression level was significantly reduced in persons with IGR and T2DM carrying 
      the L/L (GT)(n) genotype compared with persons with the S/S genotype. Further 
      haplotype combination assay confirmed the functional dominance of the (GT)(n) 
      microsatellite polymorphism over the T(-413)A single nucleotide polymorphism. 
      These results support an association between the HO-1 (GT)(n) microsatellite 
      polymorphism, HO-1 expression levels, and the odds of T2DM.
FAU - Song, Fangfang
AU  - Song F
AD  - Department of Nutrition and Food Hygiene and MOE Key Laboratory of Environment 
      and Health, School of Public Health, Tongji Medical College, Huazhong University 
      of Science and Technology, Wuhan, People's Republic of China.
FAU - Li, Xiangyang
AU  - Li X
FAU - Zhang, Muxun
AU  - Zhang M
FAU - Yao, Ping
AU  - Yao P
FAU - Yang, Nianhong
AU  - Yang N
FAU - Sun, Xiufa
AU  - Sun X
FAU - Hu, Frank B
AU  - Hu FB
FAU - Liu, Liegang
AU  - Liu L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090820
PL  - United States
TA  - Am J Epidemiol
JT  - American journal of epidemiology
JID - 7910653
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Confidence Intervals
MH  - Diabetes Mellitus, Type 2/enzymology/epidemiology/*genetics
MH  - Female
MH  - Genotype
MH  - Heme Oxygenase-1/biosynthesis/*genetics/metabolism
MH  - Humans
MH  - Male
MH  - Microsatellite Repeats
MH  - Middle Aged
MH  - Odds Ratio
MH  - *Polymorphism, Genetic
MH  - Statistics as Topic
MH  - Surveys and Questionnaires
EDAT- 2009/08/22 09:00
MHDA- 2009/09/24 06:00
CRDT- 2009/08/22 09:00
PHST- 2009/08/22 09:00 [entrez]
PHST- 2009/08/22 09:00 [pubmed]
PHST- 2009/09/24 06:00 [medline]
AID - kwp196 [pii]
AID - 10.1093/aje/kwp196 [doi]
PST - ppublish
SO  - Am J Epidemiol. 2009 Sep 15;170(6):747-56. doi: 10.1093/aje/kwp196. Epub 2009 Aug 
      20.