PMID- 19699129
OWN - NLM
STAT- MEDLINE
DCOM- 20100628
LR  - 20131121
IS  - 1878-3511 (Electronic)
IS  - 1201-9712 (Linking)
VI  - 14
IP  - 4
DP  - 2010 Apr
TI  - Correlation between the concentrations of tumor necrosis factor-alpha and the 
      severity of disease in patients infected with Orientia tsutsugamushi.
PG  - e328-33
LID - 10.1016/j.ijid.2009.06.002 [doi]
AB  - BACKGROUND: Patients with tsutsugamushi disease sometimes die if they do not 
      receive appropriate chemotherapy. This study measured the concentration of 
      several cytokines both before and after the administration of tetracyclines, and 
      evaluated the changes in cytokine levels in patient serum to investigate the 
      relationship between serum levels of cytokines and disease severity. METHODS: A 
      total of nine patients were infected with Orientia tsutsugamushi. The diagnosis 
      of tsutsugamushi disease was made using an indirect immunoperoxidase antibody 
      test. The serum concentrations of cytokines were measured using enzyme-linked 
      immunosorbent assays. RESULTS: The levels of interleukin (IL)-10 (mean 71.7 
      pg/ml) and IL-12p40 (mean 588 pg/ml) were elevated in all patients in the acute 
      phase, above the normal upper limits. Tumor necrosis factor-alpha (TNF-alpha) 
      levels (mean 9.20 pg/ml) were elevated in 89% and interferon-gamma (IFN-gamma) 
      levels (mean 41.0 pg/ml) in 44% of patients. The down-regulation of these 
      overproduced cytokines was observed after chemotherapy. There was a significant 
      correlation between the concentrations of TNF-alpha in the acute phase and the 
      severity of disease (r=0.918). CONCLUSION: The concentration of TNF-alpha may 
      predict the severity of tsutsugamushi disease in the acute infectious phase.
FAU - Iwasaki, Hiromichi
AU  - Iwasaki H
AD  - First Department of Internal Medicine, Faculty of Medical Science, University of 
      Fukui, Matsuoka, Fukui, Japan. hiwasaki@u-fukui.ac.jp
FAU - Mizoguchi, Jiro
AU  - Mizoguchi J
FAU - Takada, Nobuhiro
AU  - Takada N
FAU - Tai, Katsunori
AU  - Tai K
FAU - Ikegaya, Satoshi
AU  - Ikegaya S
FAU - Ueda, Takanori
AU  - Ueda T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090820
PL  - Canada
TA  - Int J Infect Dis
JT  - International journal of infectious diseases : IJID : official publication of the 
      International Society for Infectious Diseases
JID - 9610933
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Interleukin-12 Subunit p40)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
RN  - F8VB5M810T (Tetracycline)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Bacterial Agents/*administration & dosage
MH  - Female
MH  - Humans
MH  - Interferon-gamma/blood
MH  - Interleukin-10/blood
MH  - Interleukin-12 Subunit p40/blood
MH  - Interleukin-4/blood
MH  - Male
MH  - Middle Aged
MH  - Orientia tsutsugamushi/*growth & development
MH  - Scrub Typhus/drug therapy/*immunology/parasitology
MH  - Severity of Illness Index
MH  - Tetracycline/*administration & dosage
MH  - Tumor Necrosis Factor-alpha/*blood
EDAT- 2009/08/25 09:00
MHDA- 2010/06/29 06:00
CRDT- 2009/08/25 09:00
PHST- 2009/03/27 00:00 [received]
PHST- 2009/05/31 00:00 [revised]
PHST- 2009/06/01 00:00 [accepted]
PHST- 2009/08/25 09:00 [entrez]
PHST- 2009/08/25 09:00 [pubmed]
PHST- 2010/06/29 06:00 [medline]
AID - S1201-9712(09)00241-0 [pii]
AID - 10.1016/j.ijid.2009.06.002 [doi]
PST - ppublish
SO  - Int J Infect Dis. 2010 Apr;14(4):e328-33. doi: 10.1016/j.ijid.2009.06.002. Epub 
      2009 Aug 20.