PMID- 19699265
OWN - NLM
STAT- MEDLINE
DCOM- 20091109
LR  - 20231105
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 464
IP  - 3
DP  - 2009 Oct 30
TI  - Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 
      mice.
PG  - 184-7
LID - 10.1016/j.neulet.2009.08.038 [doi]
AB  - Caloric restriction (CR) mitigates neurological damage arising from aging and a 
      variety of other sources, including neuropathology in young adult mice that 
      express single and double transgenic (tg) mutations associated with Alzheimer 
      disease (AD). To evaluate the potential of CR to protect against relatively heavy 
      AD-type pathology, middle-aged (13-14-month-old) mice that co-express two 
      mutations related to familial AD, amyloid precursor protein (APP) and presenilin 
      1 (PS1), were fed balanced diets with 40% fewer calories than ad libitum-fed 
      controls. Following 18 weeks of treatment, mice were killed and brains were 
      processed for quantification of total volume of amyloid-beta (Abeta) in the 
      hippocampal formation and the overlying neocortex. Computerized stereology 
      confirmed that CR reduced the total Abeta volume by about one-third compared to 
      that in age-matched controls. Thus, CR appears to attenuate the accumulation of 
      AD-type neuropathology in two cortical brain regions of middle-aged dtg APP/PS1 
      mice. These findings support the view that CR could be a potentially effective, 
      non-pharmacology strategy for reducing relatively heavy Abeta deposition in older 
      adult dtg APP/PS1 mice, and possibly afford similar protection against the onset 
      and progression of AD in older adult humans.
FAU - Mouton, Peter R
AU  - Mouton PR
AD  - Laboratory of Experimental Gerontology, Gerontology Research Center, National 
      Institute on Aging, Baltimore, MD 21224, United States. Moutonpe@mail.nih.gov
FAU - Chachich, Mark E
AU  - Chachich ME
FAU - Quigley, Christopher
AU  - Quigley C
FAU - Spangler, Edward
AU  - Spangler E
FAU - Ingram, Donald K
AU  - Ingram DK
LA  - eng
GR  - R44 MH076541/MH/NIMH NIH HHS/United States
GR  - R44 MH076541-03/MH/NIMH NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
GR  - MH076541/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20090820
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Amyloid beta-Peptides)
SB  - IM
MH  - Aging/*metabolism
MH  - Amyloid beta-Peptides/*metabolism
MH  - Animals
MH  - *Caloric Restriction
MH  - Hippocampus/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - Neocortex/*metabolism
PMC - PMC2748166
MID - NIHMS140191
EDAT- 2009/08/25 09:00
MHDA- 2009/11/10 06:00
PMCR- 2010/10/30
CRDT- 2009/08/25 09:00
PHST- 2009/06/24 00:00 [received]
PHST- 2009/08/13 00:00 [revised]
PHST- 2009/08/15 00:00 [accepted]
PHST- 2009/08/25 09:00 [entrez]
PHST- 2009/08/25 09:00 [pubmed]
PHST- 2009/11/10 06:00 [medline]
PHST- 2010/10/30 00:00 [pmc-release]
AID - S0304-3940(09)01118-5 [pii]
AID - 10.1016/j.neulet.2009.08.038 [doi]
PST - ppublish
SO  - Neurosci Lett. 2009 Oct 30;464(3):184-7. doi: 10.1016/j.neulet.2009.08.038. Epub 
      2009 Aug 20.