PMID- 19699885
OWN - NLM
STAT- MEDLINE
DCOM- 20090914
LR  - 20161125
IS  - 1552-6259 (Electronic)
IS  - 0003-4975 (Linking)
VI  - 88
IP  - 3
DP  - 2009 Sep
TI  - Neurohormonal and echocardiographic results after CorCap and mitral annuloplasty 
      for dilated cardiomyopathy.
PG  - 719-25
LID - 10.1016/j.athoracsur.2009.05.050 [doi]
AB  - BACKGROUND: Restrictive mitral annuloplasty (RMA) can be an effective treatment 
      for functional mitral regurgitation in congestive heart failure (CHF). Passive 
      cardiac restraint is another surgical approach, but the midterm results are not 
      well characterized. METHODS: Thirty patients with functional mitral regurgitation 
      were prospectively randomized to RMA alone or cardiac restraint with the CorCap 
      Cardiac Support Device (Acorn Cardiovascular Inc, St. Paul, MN) and RMA. 
      Clinical, echocardiographic, New York Heart Association (NYHA) functional class, 
      Short Form 36-Item Health Survey (SF-36) quality of life scores, and N-terminal 
      pro-B-type natriuretic peptide (NT-proBNP) results were analyzed. RESULTS: No 
      hospital deaths or device-related complications occurred. The two groups had 
      comparable morbidity (p = 0.34). Echocardiography showed a trend towards a 
      slightly better functional improvement during follow-up in CorCap plus RMA 
      patients (between groups, p = 0.001). Both groups showed improved results for 
      SF-36, NYHA, and NT-pro.BNP; however, CorCap plus RMA patients had significantly 
      better SF-36 at discharge (p = 0.003), postoperative NYHA (p = 0.05), and 
      NT-pro.BNP (p = 0.001). Survival (p = 0.46), freedom from CHF (p = 0.23), and 
      rehospitalization (p = 0.28) were comparable. Patients in whom CHF developed 
      after postoperative day 1 had higher NT-pro.BNP values (p = 0.001 at all 
      time-points). CONCLUSIONS: Adjunctive application of CorCap with RMA correlated 
      with better NT-pro.BNP at short-term follow-up together with slightly improved 
      echocardiographic and functional results. This deserves further evaluation at 
      midterm and long-term follow-up. Reduction of NT-pro.BNP at follow-up may be 
      suggested as a prognostic index.
FAU - Rubino, Antonio S
AU  - Rubino AS
AD  - Cardiac Surgery Unit, Magna Graecia University of Catanzaro, Catanzaro, Italy. 
      cchumg@hotmail.it
FAU - Onorati, Francesco
AU  - Onorati F
FAU - Santarpino, Giuseppe
AU  - Santarpino G
FAU - Pasceri, Eugenia
AU  - Pasceri E
FAU - Santarpia, Giuseppe
AU  - Santarpia G
FAU - Cristodoro, Lucia
AU  - Cristodoro L
FAU - Serraino, Giuseppe Filiberto
AU  - Serraino GF
FAU - Renzulli, Attilio
AU  - Renzulli A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Netherlands
TA  - Ann Thorac Surg
JT  - The Annals of thoracic surgery
JID - 15030100R
RN  - 0 (Peptide Fragments)
RN  - 0 (Polyesters)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
CIN - Ann Thorac Surg. 2009 Sep;88(3):726. PMID: 19699886
CIN - Ann Thorac Surg. 2010 Apr;89(4):1344-5; author reply 1345. PMID: 20338390
MH  - Aged
MH  - Cardiomyopathy, Dilated/blood/diagnostic imaging/mortality/*surgery
MH  - Combined Modality Therapy
MH  - *Echocardiography
MH  - Echocardiography, Doppler, Color
MH  - Echocardiography, Transesophageal
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/blood/diagnostic imaging/mortality/*surgery
MH  - *Heart Valve Prosthesis
MH  - *Heart-Assist Devices
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve/diagnostic imaging/*surgery
MH  - Mitral Valve Insufficiency/blood/diagnostic imaging/mortality/*surgery
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - *Polyesters
MH  - Postoperative Complications/blood/diagnostic imaging/mortality
MH  - *Surgical Mesh
MH  - Ventricular Dysfunction, Left/blood/diagnostic imaging/mortality/*surgery
EDAT- 2009/08/25 09:00
MHDA- 2009/09/15 06:00
CRDT- 2009/08/25 09:00
PHST- 2009/03/02 00:00 [received]
PHST- 2009/05/15 00:00 [revised]
PHST- 2009/05/18 00:00 [accepted]
PHST- 2009/08/25 09:00 [entrez]
PHST- 2009/08/25 09:00 [pubmed]
PHST- 2009/09/15 06:00 [medline]
AID - S0003-4975(09)01053-4 [pii]
AID - 10.1016/j.athoracsur.2009.05.050 [doi]
PST - ppublish
SO  - Ann Thorac Surg. 2009 Sep;88(3):719-25. doi: 10.1016/j.athoracsur.2009.05.050.