PMID- 19700469
OWN - NLM
STAT- MEDLINE
DCOM- 20110111
LR  - 20220317
IS  - 1522-9645 (Electronic)
IS  - 0195-668X (Linking)
VI  - 30
IP  - 24
DP  - 2009 Dec
TI  - Abnormal coronary reserve and left ventricular wall motion during cold pressor 
      test in patients with previous left ventricular ballooning syndrome.
PG  - 3007-14
LID - 10.1093/eurheartj/ehp325 [doi]
AB  - AIMS: To investigate whether and how cold pressor test (CPT) could affect 
      myocardial perfusion and left ventricular (LV) function in patients with previous 
      LV ballooning syndrome (LVBS). METHODS AND RESULTS: Cold pressor test (3 min hand 
      immersion in ice-water) was performed in 17 women with previous LVBS and in 7 
      age- and risk factor-matched women with chest pain and normal coronary arteries. 
      At baseline and peak CPT, global and regional LV function, and myocardial 
      perfusion were quantitatively assessed by real-time three-dimensional 
      echocardiography (RT3DE) and myocardial contrast (SonoVue, Bracco) 2D 
      echocardiography (MCE), respectively (Philips iE33 machine, X3-1 and S5-1 
      probes). Data were analysed off-line (QLab 6.0 software). Peripheral venous 
      catecholamines were assayed by high performance liquid chromatography with 
      electrochemical detection. Cold pressor test induced similar haemodynamic changes 
      and catecholamine increase in controls and LVBS patients. Left ventricular 
      ejection fraction decreased and transient new mid-ventricular and apical motion 
      abnormalities developed in LVBS patients only (quantitative RT3D analysis), 
      without corresponding perfusion defects (MCE). At peak CPT, coronary blood flow 
      and velocity increased (quantitative MCE analysis) in control subjects only. 
      CONCLUSION: Cold pressor test induced LV wall motion abnormalities unmatched to 
      regional coronary flow reduction in LVBS patients only. The reduced coronary 
      reserve in response to CPT suggests microvascular dysfunction in LVBS patients.
FAU - Barletta, Giuseppe
AU  - Barletta G
AD  - Non Invasive Cardiology, Department of Heart and Vessels, AOU Careggi, Florence 
      50134, Italy. barlettagius@tiscali.it
FAU - Del Pace, Stefano
AU  - Del Pace S
FAU - Boddi, Maria
AU  - Boddi M
FAU - Del Bene, Riccarda
AU  - Del Bene R
FAU - Salvadori, Claudia
AU  - Salvadori C
FAU - Bellandi, Benedetta
AU  - Bellandi B
FAU - Coppo, Mirella
AU  - Coppo M
FAU - Saletti, Elisa
AU  - Saletti E
FAU - Gensini, Gian Franco
AU  - Gensini GF
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Cold Temperature
MH  - Echocardiography, Three-Dimensional
MH  - Epinephrine/metabolism
MH  - Female
MH  - Fractional Flow Reserve, Myocardial/*physiology
MH  - Humans
MH  - Microcirculation/physiology
MH  - Middle Aged
MH  - Norepinephrine/metabolism
MH  - Takotsubo Cardiomyopathy/*physiopathology
MH  - Ventricular Dysfunction, Left/*physiopathology
EDAT- 2009/08/25 09:00
MHDA- 2011/01/12 06:00
CRDT- 2009/08/25 09:00
PHST- 2009/08/25 09:00 [entrez]
PHST- 2009/08/25 09:00 [pubmed]
PHST- 2011/01/12 06:00 [medline]
AID - ehp325 [pii]
AID - 10.1093/eurheartj/ehp325 [doi]
PST - ppublish
SO  - Eur Heart J. 2009 Dec;30(24):3007-14. doi: 10.1093/eurheartj/ehp325.