PMID- 19700612
OWN - NLM
STAT- MEDLINE
DCOM- 20100126
LR  - 20111117
IS  - 1933-7205 (Electronic)
IS  - 1933-7191 (Linking)
VI  - 16
IP  - 12
DP  - 2009 Dec
TI  - Possible gene-gene interaction of KIR2DL4 with its cognate ligand HLA-G in 
      modulating risk for preeclampsia.
PG  - 1135-43
LID - 10.1177/1933719109342280 [doi]
AB  - Preeclampsia (PE) is a leading cause of maternal and fetal mortality and 
      morbidity that occurs only during pregnancy. Pregnancy is the only physiological 
      situation where killer-cell immunoglobulin-like receptors (KIRs) may meet cognate 
      nonself variants of human leukocyte antigen (HLA) allotypes. We previously 
      reported that presence of fetal HLA-G*0106 was significantly associated with risk 
      for PE in multigravid pregnancies. We have now tested the KIR2DL4 receptor gene 
      for association with PE, as well as for its interaction with HLA-G in modulating 
      disease risk, in a case-control study of 83 PE and 240 normotensive pregnancies. 
      No significant association was observed between alleles of KIR2DL4 and PE in both 
      maternal and fetal groups, either among primigravid or multigravid pregnancies. 
      Alleles of KIR2DL4 and HLA-G were then analyzed together to determine whether 
      particular variant ligand-receptor combinations were associated with an increased 
      risk for PE. Gene-gene interaction analyses suggest that the presence of fetal 
      HLA-G*0106 in combination with maternal KIR2DL4*006 is significantly associated 
      with PE risk in multigravid pregnancies (P < .001). These data provide the first 
      preliminary evidence suggesting that although KIR2DL4 itself is not associated 
      with PE, it may modulate the effect of HLA-G*0106 on risk for PE.
FAU - Tan, Chia Yee
AU  - Tan CY
AD  - Department of Pediatrics, Yong Loo Lin School of Medicine, National University of 
      Singapore, Singapore.
FAU - Chong, Yap Seng
AU  - Chong YS
FAU - Loganath, Annamalai
AU  - Loganath A
FAU - Chan, Yiong Huak
AU  - Chan YH
FAU - Ravichandran, Jeganathan
AU  - Ravichandran J
FAU - Lee, Caroline G
AU  - Lee CG
FAU - Chong, Samuel S
AU  - Chong SS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090821
PL  - United States
TA  - Reprod Sci
JT  - Reproductive sciences (Thousand Oaks, Calif.)
JID - 101291249
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (HLA-G*01:06 antigen)
RN  - 0 (KIR2DL4 protein, human)
RN  - 0 (Ligands)
RN  - 0 (Receptors, KIR2DL4)
SB  - IM
MH  - Case-Control Studies
MH  - *Epistasis, Genetic
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - HLA-G Antigens
MH  - Haplotypes
MH  - Humans
MH  - Ligands
MH  - Logistic Models
MH  - *Polymorphism, Single Nucleotide
MH  - Pre-Eclampsia/*genetics/immunology
MH  - Pregnancy
MH  - Receptors, KIR2DL4/*genetics
MH  - Risk Assessment
MH  - Risk Factors
EDAT- 2009/08/25 09:00
MHDA- 2010/01/27 06:00
CRDT- 2009/08/25 09:00
PHST- 2009/08/25 09:00 [entrez]
PHST- 2009/08/25 09:00 [pubmed]
PHST- 2010/01/27 06:00 [medline]
AID - 1933719109342280 [pii]
AID - 10.1177/1933719109342280 [doi]
PST - ppublish
SO  - Reprod Sci. 2009 Dec;16(12):1135-43. doi: 10.1177/1933719109342280. Epub 2009 Aug 
      21.