PMID- 19701757
OWN - NLM
STAT- MEDLINE
DCOM- 20100202
LR  - 20211020
IS  - 1437-9813 (Electronic)
IS  - 0179-0358 (Linking)
VI  - 25
IP  - 11
DP  - 2009 Nov
TI  - Outcome of pediatric renal tumor treated using the Japan Wilms Tumor Study-1 
      (JWiTS-1) protocol: a report from the JWiTS group.
PG  - 923-9
LID - 10.1007/s00383-009-2449-0 [doi]
AB  - PURPOSE: In 1996, the Japan Wilms Tumor Study (JWiTS) group was founded to 
      elucidate the efficacy and safety of the regimen established by the National 
      Wilms Tumor Study (NWTS) group in the USA, and a multicenter cooperative study 
      (JWiTS-1) was started in Japan. This report reviews the results of JWiTS-1. 
      METHODS: A total of 307 patients with malignant renal tumor were enrolled in the 
      JWiTS-1 study between 1996 and 2005. Central pathological diagnosis and follow-up 
      data were available in 210 cases. The protocol regimens were similar to the 
      NWTS-5 regimens. Clinical stage was classified according to the Japanese Staging 
      System. RESULTS: Five-year overall survival (OS) rate was 91.1% for 
      nephroblastoma, 72.9% for clear cell sarcoma of the kidney (CCSK), and 22.2% for 
      rhabdoid tumor of the kidney (RTK). In the nephroblastoma patients, 5-year OS was 
      90.5% for stage I disease, 92.2% for stage II, 90.9% for stage III, 86.7% for 
      stage IV, and 78.7% for stage V. CONCLUSIONS: The OS of patients in the JWiTS-1 
      study were comparable with the results of other multicenter studies in the USA 
      and Europe. The outcome for patients with nephroblastoma and CCSK was fair. In 
      contrast, the cure rate for those with RTK was not satisfactory. New treatment 
      strategies are needed for patients with RTK.
FAU - Oue, Takaharu
AU  - Oue T
AD  - Division of Pediatric Surgery, Department of Surgery, Osaka University Graduate 
      School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. 
      ooue@pedsurg.med.osaka-u.ac.jp
FAU - Fukuzawa, Masahiro
AU  - Fukuzawa M
FAU - Okita, Hajime
AU  - Okita H
FAU - Mugishima, Hideo
AU  - Mugishima H
FAU - Horie, Hiroshi
AU  - Horie H
FAU - Hata, Jun-ichi
AU  - Hata J
FAU - Saito, Masahiro
AU  - Saito M
FAU - Nozaki, Miwako
AU  - Nozaki M
FAU - Chin, Motoaki
AU  - Chin M
FAU - Nakadate, Hisaya
AU  - Nakadate H
FAU - Hinotsu, Shiro
AU  - Hinotsu S
FAU - Koshinaga, Tsugumichi
AU  - Koshinaga T
FAU - Kaneko, Yasuhiko
AU  - Kaneko Y
FAU - Kitano, Yoshihiro
AU  - Kitano Y
FAU - Tanaka, Yukichi
AU  - Tanaka Y
CN  - Japan Wilms Tumor Study (JWiTS) Group
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Pediatr Surg Int
JT  - Pediatric surgery international
JID - 8609169
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Kidney Neoplasms/mortality/*therapy
MH  - Male
MH  - Rhabdoid Tumor/mortality/*therapy
MH  - Sarcoma, Clear Cell/mortality/*therapy
MH  - Survival Rate
MH  - Wilms Tumor/mortality/*therapy
EDAT- 2009/08/25 09:00
MHDA- 2010/02/03 06:00
CRDT- 2009/08/25 09:00
PHST- 2009/08/25 09:00 [entrez]
PHST- 2009/08/25 09:00 [pubmed]
PHST- 2010/02/03 06:00 [medline]
AID - 10.1007/s00383-009-2449-0 [doi]
PST - ppublish
SO  - Pediatr Surg Int. 2009 Nov;25(11):923-9. doi: 10.1007/s00383-009-2449-0.