PMID- 19701914
OWN - NLM
STAT- MEDLINE
DCOM- 20100329
LR  - 20200930
IS  - 1552-4981 (Electronic)
IS  - 1552-4973 (Linking)
VI  - 92
IP  - 1
DP  - 2010 Jan
TI  - In vivo evaluation of noble metal coatings.
PG  - 86-94
LID - 10.1002/jbm.b.31492 [doi]
AB  - A nanotopographic noble metal (Ag, Au, Pd) coating has been applied on commercial 
      urinary catheters and used in more than 80,000 patients, with good clinical 
      results. We have previously evaluated the biocompatibility of different 
      variations of this coating, showing high cellular viability and function in 
      vitro. However, the reasons for good clinical and preclinical behavior are not 
      known. This in vivo study aimed to investigate the soft tissue peri-implant 
      reaction to five coatings with systematically altered noble metal ratios after 1, 
      3, and 21 days of implantation in rats. The results show that coatings of silver 
      only, or silver with medium amounts of gold and low-medium palladium content were 
      superior to other tested coatings. Such surfaces were during the first days after 
      implantation associated with a decreased recruitment of inflammatory cells to 
      implant close exudates, a lower percentage of neutrophils, higher cell viability, 
      and lower production of monocyte chemoattractant protein-1 (MCP-1), compared to 
      the other coatings and uncoated silicone (PDMS) control. In contrast, the 
      addition of higher concentrations of gold and palladium to silver induced a 
      thicker soft tissue capsule. Coatings with high concentration of palladium 
      induced the thickest fibrouscapsule after 21 days of implantation. The study 
      demonstrates that by varying the noble metal ratio at implant surfaces it is 
      possible to modulate inflammation and fibrosis in soft tissue.
CI  - (c) 2009 Wiley Periodicals, Inc.
FAU - Suska, Felicia
AU  - Suska F
AD  - Department of Biomaterials, Sahlgrenska Academy at University of Gothenburg, 
      Gothenburg, Sweden.
FAU - Svensson, Sara
AU  - Svensson S
FAU - Johansson, Anna
AU  - Johansson A
FAU - Emanuelsson, Lena
AU  - Emanuelsson L
FAU - Karlholm, Helen
AU  - Karlholm H
FAU - Ohrlander, Mattias
AU  - Ohrlander M
FAU - Thomsen, Peter
AU  - Thomsen P
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biomed Mater Res B Appl Biomater
JT  - Journal of biomedical materials research. Part B, Applied biomaterials
JID - 101234238
RN  - 0 (Biocompatible Materials)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Metals)
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Animals
MH  - *Biocompatible Materials
MH  - Cell Survival
MH  - Chemokine CCL2/metabolism
MH  - Female
MH  - *Metals
MH  - Microscopy, Atomic Force
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Transforming Growth Factor beta1/metabolism
EDAT- 2009/08/25 09:00
MHDA- 2010/03/30 06:00
CRDT- 2009/08/25 09:00
PHST- 2009/08/25 09:00 [entrez]
PHST- 2009/08/25 09:00 [pubmed]
PHST- 2010/03/30 06:00 [medline]
AID - 10.1002/jbm.b.31492 [doi]
PST - ppublish
SO  - J Biomed Mater Res B Appl Biomater. 2010 Jan;92(1):86-94. doi: 
      10.1002/jbm.b.31492.