PMID- 19702519
OWN - NLM
STAT- MEDLINE
DCOM- 20091109
LR  - 20220408
IS  - 1873-5592 (Electronic)
IS  - 1389-4501 (Linking)
VI  - 10
IP  - 8
DP  - 2009 Aug
TI  - Clinical uses of low-dose ketamine in patients undergoing surgery.
PG  - 707-15
AB  - Ketamine acts mainly as a N-methyl-D-aspartate receptor (NMDAr) antagonist. 
      Originally developed as a general anesthetic, it is now seldom employed as such 
      in richer countries due to the relatively high risk of psychotomimetic adverse 
      effects. Recently, low-dose regimens in the range of 0.25-0.5 mg/kg as an initial 
      bolus followed by 50-500 kappag/kg/h have been proposed as an adjuvant for 
      postoperative analgesia and for the reduction of exogenous opioid-induced 
      hyperalgesia. In this review, we examine the evidence for clinical usefulness of 
      perioperative ketamine infusion and its role in the context of general and/or 
      regional anesthesia.
FAU - Berti, M
AU  - Berti M
AD  - Department of Anesthesiology, Critical Care and Pain Medicine, University 
      Hospital of Parma, Parma, Italy. mberti@ao.pr.it
FAU - Baciarello, M
AU  - Baciarello M
FAU - Troglio, R
AU  - Troglio R
FAU - Fanelli, G
AU  - Fanelli G
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Drug Targets
JT  - Current drug targets
JID - 100960531
RN  - 0 (Anesthetics, Dissociative)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 690G0D6V8H (Ketamine)
SB  - IM
MH  - Anesthesia, General
MH  - Anesthesia, Local
MH  - Anesthetics, Dissociative/administration & dosage/*therapeutic use
MH  - Dose-Response Relationship, Drug
MH  - Excitatory Amino Acid Antagonists/administration & dosage/*therapeutic use
MH  - Humans
MH  - Ketamine/administration & dosage/*therapeutic use
MH  - Pain, Postoperative/physiopathology/prevention & control
RF  - 71
EDAT- 2009/08/26 09:00
MHDA- 2009/11/10 06:00
CRDT- 2009/08/26 09:00
PHST- 2009/08/26 09:00 [entrez]
PHST- 2009/08/26 09:00 [pubmed]
PHST- 2009/11/10 06:00 [medline]
AID - 10.2174/138945009788982496 [doi]
PST - ppublish
SO  - Curr Drug Targets. 2009 Aug;10(8):707-15. doi: 10.2174/138945009788982496.