PMID- 19702660
OWN - NLM
STAT- MEDLINE
DCOM- 20100114
LR  - 20211020
IS  - 1600-0684 (Electronic)
IS  - 0047-2565 (Print)
IS  - 0047-2565 (Linking)
VI  - 38
IP  - 6
DP  - 2009 Dec
TI  - Association of monocyte chemoattractant protein-1 with adipocyte number, insulin 
      resistance and liver function markers.
PG  - 418-24
LID - 10.1111/j.1600-0684.2009.00379.x [doi]
AB  - BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) is an inflammatory 
      chemokine known to induce adipocyte dedifferentiation and insulin resistance. 
      Inflammation, insulin resistance, and obesity have been implicated in the 
      pathogenesis of non-alcoholic fatty liver disease (NAFLD). METHODS: Fasting 
      plasma from 43 baboons were assayed for MCP-1, insulin, glucose, alanine 
      aminotransferase (ALT), and aspartate aminotransferase (AST). Adipocyte number 
      and volume were measured via biopsies of omental adipose tissue. The homeostatic 
      model assessment method (HOMA) was used to estimate systemic insulin resistance. 
      RESULTS: Sex and age adjusted correlations were significant for MCP-1 with 
      adipocyte number (r = -0.42; P = 0.01), adipocyte volume (r = 0.38; P = 0.02), 
      HOMA (r = 0.45; P = 0.004), ALT (r = 0.46; P = 0.03) and AST (r = 0.45; P = 
      0.03). CONCLUSIONS: These results suggest that MCP-1 is related with adipocyte 
      dedifferentiation and systemic insulin resistance, thereby potentially 
      contributing to the development of NAFLD.
FAU - Bose, Tanushree
AU  - Bose T
AD  - Division of Nutritional Sciences, Department of Human Ecology, The University of 
      Texas at Austin, Austin, TX, USA. tbose@calpoly.edu
FAU - Alvarenga, Juan Carlos Lopez
AU  - Alvarenga JC
FAU - Tejero, M Elizabeth
AU  - Tejero ME
FAU - Voruganti, V Saroja
AU  - Voruganti VS
FAU - Proffitt, J Michael
AU  - Proffitt JM
FAU - Freeland-Graves, Jeanne H
AU  - Freeland-Graves JH
FAU - Cole, Shelley A
AU  - Cole SA
FAU - Comuzzie, Anthony G
AU  - Comuzzie AG
LA  - eng
GR  - P51 RR013986-11/RR/NCRR NIH HHS/United States
GR  - C06 RR017515/RR/NCRR NIH HHS/United States
GR  - C06 RR013556/RR/NCRR NIH HHS/United States
GR  - MH59490/MH/NIMH NIH HHS/United States
GR  - R01 MH059490/MH/NIMH NIH HHS/United States
GR  - C06 RR014578/RR/NCRR NIH HHS/United States
GR  - C06 RR015456/RR/NCRR NIH HHS/United States
GR  - P51 RR013986/RR/NCRR NIH HHS/United States
GR  - RR013986/RR/NCRR NIH HHS/United States
GR  - P01 HL028972/HL/NHLBI NIH HHS/United States
GR  - R37 MH059490/MH/NIMH NIH HHS/United States
GR  - HL28972/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20090821
PL  - Denmark
TA  - J Med Primatol
JT  - Journal of medical primatology
JID - 0320626
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Alanine Transaminase/blood
MH  - Animals
MH  - Aspartate Aminotransferases/blood
MH  - Biomarkers/blood
MH  - Chemokine CCL2/*blood
MH  - Fatty Liver/blood/*etiology/pathology
MH  - Female
MH  - Inflammation/blood/*complications
MH  - *Insulin Resistance
MH  - Intra-Abdominal Fat/*pathology
MH  - Liver Function Tests
MH  - Male
MH  - Papio hamadryas
PMC - PMC2783443
MID - NIHMS146001
EDAT- 2009/08/26 09:00
MHDA- 2010/01/15 06:00
PMCR- 2009/12/01
CRDT- 2009/08/26 09:00
PHST- 2009/08/26 09:00 [entrez]
PHST- 2009/08/26 09:00 [pubmed]
PHST- 2010/01/15 06:00 [medline]
PHST- 2009/12/01 00:00 [pmc-release]
AID - JMP379 [pii]
AID - 10.1111/j.1600-0684.2009.00379.x [doi]
PST - ppublish
SO  - J Med Primatol. 2009 Dec;38(6):418-24. doi: 10.1111/j.1600-0684.2009.00379.x. 
      Epub 2009 Aug 21.