PMID- 19702900
OWN - NLM
STAT- MEDLINE
DCOM- 20091102
LR  - 20090825
IS  - 1440-1746 (Electronic)
IS  - 0815-9319 (Linking)
VI  - 24
IP  - 8
DP  - 2009 Aug
TI  - Meta-analysis used to identify factors associated with the effectiveness of 
      proton pump inhibitors against non-erosive reflux disease.
PG  - 1326-32
LID - 10.1111/j.1440-1746.2009.05879.x [doi]
AB  - BACKGROUND: A lack of published data remains on factors associated with the 
      treatment response to proton pump inhibitors (PPI) in patients with non-erosive 
      reflux disease (NERD). METHODS: Studies on effectiveness of PPI in patients with 
      NERD were identified using the MEDLINE database and manual searches of the 
      available literature. Twenty publications that comprised a total of 22 study arms 
      were eligible, and meta-analyses of these 22 study arms were carried out. 
      RESULTS: Overall improvement rate in patients with PPI was 68%. Univariate 
      meta-regression analysis was used to explore the source of heterogeneity, P-value 
      for males was 0.192, and in the presence of Helicobacter pylori (H. pylori) 
      infection was 0.186, indicating that these factors are associated with treatment 
      effectiveness. Thus, as the frequency of male and H. pylori-infected patients 
      increased, the effectiveness of PPI against NERD improved. By multivariate 
      meta-regression analysis, the P-value for male and H. pylori infection decreased 
      further (P = 0.002 and P = 0.003, respectively), indicating little interaction 
      between male sex and H. pylori infection. CONCLUSION: These results suggest that 
      H. pylori infection and patient sex may be associated with the effectiveness of 
      PPI against patients with NERD. The reasons are still unclear, and further 
      examinations are needed to clarify them.
FAU - Hiyama, Toru
AU  - Hiyama T
AD  - Health Service Center, Hiroshima University, Higashihiroshima, Japan. 
      tohiyama@hiroshima-u.ac.jp
FAU - Matsuo, Keitaro
AU  - Matsuo K
FAU - Urabe, Yuji
AU  - Urabe Y
FAU - Fukuhara, Tatsuma
AU  - Fukuhara T
FAU - Tanaka, Shinji
AU  - Tanaka S
FAU - Yoshihara, Masaharu
AU  - Yoshihara M
FAU - Haruma, Ken
AU  - Haruma K
FAU - Chayama, Kazuaki
AU  - Chayama K
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Esophagitis, Peptic/*drug therapy/microbiology
MH  - Female
MH  - Gastroesophageal Reflux/*drug therapy/microbiology
MH  - Helicobacter Infections/microbiology
MH  - Helicobacter pylori/pathogenicity
MH  - Humans
MH  - Male
MH  - Patient Selection
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Sex Factors
MH  - Treatment Outcome
RF  - 41
EDAT- 2009/08/26 09:00
MHDA- 2009/11/03 06:00
CRDT- 2009/08/26 09:00
PHST- 2009/08/26 09:00 [entrez]
PHST- 2009/08/26 09:00 [pubmed]
PHST- 2009/11/03 06:00 [medline]
AID - JGH5879 [pii]
AID - 10.1111/j.1440-1746.2009.05879.x [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2009 Aug;24(8):1326-32. doi: 
      10.1111/j.1440-1746.2009.05879.x.