PMID- 19703512
OWN - NLM
STAT- MEDLINE
DCOM- 20100423
LR  - 20131121
IS  - 1638-6183 (Electronic)
IS  - 0300-9084 (Linking)
VI  - 91
IP  - 11-12
DP  - 2009 Nov-Dec
TI  - Natural compounds and the hypoxia-inducible factor (HIF) signalling pathway.
PG  - 1347-58
LID - 10.1016/j.biochi.2009.08.005 [doi]
AB  - A decline in the tissue oxygen level below normal leads to cellular hypoxia. This 
      situation is very frequently encountered in solid tumors as existing blood 
      vessels cannot satisfy the requirements in oxygen of the rapidly growing tumor. 
      Like hyperoxia, hypoxia is a stress factor for cells and tissues. Adapting to 
      this stressful situation leads to activation of the dimeric transcription factor 
      hypoxia-inducible factor-1 (HIF-1) that induces gene expression in promoting 
      tumor cell survival. In addition, hypoxia acts as a selection factor for radio- 
      and chemotherapy resistant tumor cells with a high potential of malignancy. 
      Consequently, over expression of the HIF-1alpha subunit is associated with an 
      advanced disease stage and poor prognosis of cancer patients. During the last few 
      years intense effort has been made in investigating natural compounds that can be 
      used as HIF-1 inhibitors. These compounds aim to suppress tumor hypoxia and to 
      increase the susceptibility of tumor cells to radio- and chemo-therapy. In this 
      review we summarize recent findings concerning HIF-1 regulation and present a 
      survey of HIF-1 inhibiting natural compounds that have been discovered in the 
      last few years.
FAU - Manolescu, Bogdan
AU  - Manolescu B
AD  - Department of Biochemistry, Faculty of Medicine, University of Medicine and 
      Pharmacy Carol Davila, Bucharest, Romania. manolescub@yahoo.fr
FAU - Oprea, Eliza
AU  - Oprea E
FAU - Busu, Carmina
AU  - Busu C
FAU - Cercasov, Cornelia
AU  - Cercasov C
LA  - eng
PT  - Journal Article
DEP - 20090822
PL  - France
TA  - Biochimie
JT  - Biochimie
JID - 1264604
RN  - 0 (Biological Products)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Biological Products/*pharmacology
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/*metabolism
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
MH  - Male
MH  - Signal Transduction/*drug effects/physiology
MH  - Transcription Factors
EDAT- 2009/08/26 09:00
MHDA- 2010/04/24 06:00
CRDT- 2009/08/26 09:00
PHST- 2009/06/04 00:00 [received]
PHST- 2009/08/17 00:00 [accepted]
PHST- 2009/08/26 09:00 [entrez]
PHST- 2009/08/26 09:00 [pubmed]
PHST- 2010/04/24 06:00 [medline]
AID - S0300-9084(09)00228-4 [pii]
AID - 10.1016/j.biochi.2009.08.005 [doi]
PST - ppublish
SO  - Biochimie. 2009 Nov-Dec;91(11-12):1347-58. doi: 10.1016/j.biochi.2009.08.005. 
      Epub 2009 Aug 22.