PMID- 19705125
OWN - NLM
STAT- MEDLINE
DCOM- 20100426
LR  - 20211020
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 20
IP  - 2
DP  - 2010 Feb
TI  - Inflammation in takotsubo cardiomyopathy: insights from cardiovascular magnetic 
      resonance imaging.
PG  - 422-31
LID - 10.1007/s00330-009-1549-5 [doi]
AB  - OBJECTIVE: Takotsubo cardiomyopathy (TTC) is an increasingly recognised acute 
      cardiac syndrome, whose underlying pathophysiological mechanisms remain unknown. 
      Inflammation might play a role as this has been shown in endomyocardial biopsies. 
      The aim of this study was to assess inflammatory parameters in patients with TTC 
      using a comprehensive cardiovascular magnetic resonance imaging (CMR) approach. 
      METHODS: Thirty-seven patients with the suspected diagnosis of TTC underwent CMR. 
      T2-weighted imaging to calculate the oedema ratio, T1-weighted imaging before and 
      after contrast agent administration to calculate the global relative enhancement 
      (gRE), and late gadolinium enhancement (LGE) imaging were performed. RESULTS: In 
      11 patients CMR revealed the diagnosis of myocardial infarction (n = 7; 19%) or 
      myocarditis (n = 4; 11%) with typical patterns of LGE. In all other patients (n = 
      26; 70%), no LGE was detected consistent with the diagnosis of TTC. Of these, in 
      16 patients (62%) both inflammatory markers (oedema ratio and gRE) were elevated 
      with concomitant pericardial effusion, indicating acute inflammation. Follow-up 
      CMR after 3 months showed complete normalisation of left ventricular function and 
      inflammatory parameters in the absence of LGE and pericardial effusion. 
      CONCLUSION: This CMR study provides further insights into the pathophysiological 
      mechanisms in TTC, supporting the contribution of an inflammatory process in the 
      acute setting.
FAU - Eitel, Ingo
AU  - Eitel I
AD  - Department of Internal Medicine/Cardiology, University of Leipzig-Heart Centre, 
      Strumpellstr. 39, 04289 Leipzig, Germany. ingoeitel@gmx.de
FAU - Lucke, Christian
AU  - Lucke C
FAU - Grothoff, Matthias
AU  - Grothoff M
FAU - Sareban, Mahdi
AU  - Sareban M
FAU - Schuler, Gerhard
AU  - Schuler G
FAU - Thiele, Holger
AU  - Thiele H
FAU - Gutberlet, Matthias
AU  - Gutberlet M
LA  - eng
PT  - Journal Article
DEP - 20090825
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
SB  - IM
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Myocarditis/*diagnosis/*etiology
MH  - Takotsubo Cardiomyopathy/*complications/*diagnosis
EDAT- 2009/08/26 09:00
MHDA- 2010/04/27 06:00
CRDT- 2009/08/26 09:00
PHST- 2009/05/05 00:00 [received]
PHST- 2009/07/05 00:00 [accepted]
PHST- 2009/06/18 00:00 [revised]
PHST- 2009/08/26 09:00 [entrez]
PHST- 2009/08/26 09:00 [pubmed]
PHST- 2010/04/27 06:00 [medline]
AID - 10.1007/s00330-009-1549-5 [doi]
PST - ppublish
SO  - Eur Radiol. 2010 Feb;20(2):422-31. doi: 10.1007/s00330-009-1549-5. Epub 2009 Aug 
      25.