PMID- 19705213
OWN - NLM
STAT- MEDLINE
DCOM- 20100324
LR  - 20211020
IS  - 1476-3524 (Electronic)
IS  - 1029-8428 (Linking)
VI  - 17
IP  - 3
DP  - 2010 Apr
TI  - Depressive-like parameters in sepsis survivor rats.
PG  - 279-86
LID - 10.1007/s12640-009-9101-6 [doi]
AB  - The inflammatory and immune responses evoked in sepsis may create not only an 
      acute brain dysfunction, which occurs in the majority of septic patients, but 
      also long-term deficits such as memory impairment. In this context, we evaluated 
      depressive-like parameters in sepsis survivor rats. For this purpose, male Wistar 
      rats, weighing 300-350 g, underwent cecal ligation and perforation (CLP) (sepsis 
      group) followed by "basic support", or were sham-operated (control group). After 
      3 days of the sepsis procedure, the animals were treated with imipramine at 10 
      mg/kg or saline during 14 days (days 3-17). The consumption of sweet food was 
      measured for 7 days (days 10-17) and the body weight was measured before CLP, 10, 
      and 17 days after CLP. Seventeen days after sepsis (immediately after sweet food 
      consumption measurement), the animals were anesthetized and blood was withdrawn 
      for the analyses of corticosterone and adrenocorticotropic hormone (ACTH) levels, 
      and immediately killed by decapitation. The adrenal gland and hippocampus were 
      immediately isolated and weighed, and the hippocampus was utilized for 
      determining brain-derived neurotrophic factor (BDNF) levels. It was observed that 
      animals subjected to CLP presented decreased sucrose intake. Septic rats did not 
      increase body weight and presented an increase in the weight of adrenal gland. 
      Both corticosterone and ACTH levels were increased, while hippocampus weight and 
      BDNF levels in the hippocampus decreased. The treatment with imipramine reversed 
      all the parameters described above. Our results supported the hypothesis that 
      rats that survive sepsis show depressive-like behavior, alterations in the 
      hypothalamus-pituitary-adrenal axis, and decreased BDNF levels in the 
      hippocampus.
FAU - Comim, Clarissa M
AU  - Comim CM
AD  - Instituto Nacional de Ciencia e Tecnologia Translacional em Medicina, Unidade 
      Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 
      Criciuma, SC, Brazil.
FAU - Cassol, Omar J Jr
AU  - Cassol OJ Jr
FAU - Constantino, Leandra C
AU  - Constantino LC
FAU - Petronilho, Fabricia
AU  - Petronilho F
FAU - Constantino, Larissa S
AU  - Constantino LS
FAU - Stertz, Laura
AU  - Stertz L
FAU - Kapczinski, Flavio
AU  - Kapczinski F
FAU - Barichello, Tatiana
AU  - Barichello T
FAU - Quevedo, Joao
AU  - Quevedo J
FAU - Dal-Pizzol, Felipe
AU  - Dal-Pizzol F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090825
PL  - United States
TA  - Neurotox Res
JT  - Neurotoxicity research
JID - 100929017
RN  - 0 (Antidepressive Agents, Tricyclic)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - OGG85SX4E4 (Imipramine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adrenal Glands/drug effects
MH  - Adrenocorticotropic Hormone/blood
MH  - Analysis of Variance
MH  - Animals
MH  - Antidepressive Agents, Tricyclic/*therapeutic use
MH  - Body Weight/drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Corticosterone/blood
MH  - Depression/drug therapy/*etiology/pathology
MH  - Disease Models, Animal
MH  - Food Preferences/drug effects
MH  - Hippocampus/drug effects/metabolism/pathology
MH  - Imipramine/pharmacology/*therapeutic use
MH  - Male
MH  - Organ Size/drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Sepsis/*complications
EDAT- 2009/08/26 09:00
MHDA- 2010/03/25 06:00
CRDT- 2009/08/26 09:00
PHST- 2009/03/23 00:00 [received]
PHST- 2009/08/13 00:00 [accepted]
PHST- 2009/07/25 00:00 [revised]
PHST- 2009/08/26 09:00 [entrez]
PHST- 2009/08/26 09:00 [pubmed]
PHST- 2010/03/25 06:00 [medline]
AID - 10.1007/s12640-009-9101-6 [doi]
PST - ppublish
SO  - Neurotox Res. 2010 Apr;17(3):279-86. doi: 10.1007/s12640-009-9101-6. Epub 2009 
      Aug 25.