PMID- 19706009
OWN - NLM
STAT- MEDLINE
DCOM- 20100602
LR  - 20100310
IS  - 1365-3164 (Electronic)
IS  - 0959-4493 (Linking)
VI  - 21
IP  - 1
DP  - 2010 Feb
TI  - Low-dose recombinant canine interferon-gamma for treatment of canine atopic 
      dermatitis: an open randomized comparative trial of two doses.
PG  - 42-9
LID - 10.1111/j.1365-3164.2009.00764.x [doi]
AB  - The purpose of this study was to investigate the minimum effective dose of 
      recombinant canine interferon-gamma (rCaIFN-gamma) for the treatment of dogs with 
      atopic dermatitis (AD). Thirty-four dogs with AD from 17 animal hospitals in 
      Japan were administered half or one-fifth of the approved rCaIFN-gamma dose of 10 
      000 units/kg, three times a week for 4 weeks, followed by once weekly for an 
      additional 4 weeks. Pruritus, excoriation, erythema and alopecia were evaluated 
      and scored by the investigators on weeks 2, 4, 6, 8 and 12. The efficacy rate 
      (number of excellent cases + number of good cases/total number of cases) at week 
      8 in the 2000 units/kg group was 36.4% for pruritus, 36.4% for excoriation, 45.5% 
      for erythema and 36.4% for alopecia. In contrast, in the 5000 units/kg group, the 
      efficacy rate was 64.3% for pruritus, 57.1% for excoriation, 78.6% for erythema 
      and 78.6% for alopecia. The efficacy rate of the 5000 units/kg group was high for 
      all signs evaluated and comparable to that of the 10 000 units/kg group reported 
      in a previous study. The results of this study showed that 2000 units/kg of 
      rCaIFN-gamma is less effective than 5000 units/kg to treat dogs with AD, and the 
      efficacy of the 5000 units/kg dose is comparable to that of 10 000 units/kg at 
      week 8.
FAU - Yasukawa, Kuniyoshi
AU  - Yasukawa K
AD  - Sanyo Animal Medical Center, 357-1, Koumoto, Akaiwa, Okayama 709-0821, Japan. 
      yasu9244-vet@au8.mopera.ne.jp
FAU - Saito, Shiori
AU  - Saito S
FAU - Kubo, Takuya
AU  - Kubo T
FAU - Shibasaki, Yuya
AU  - Shibasaki Y
FAU - Yamaoka, Kayo
AU  - Yamaoka K
FAU - Hachimura, Hisae
AU  - Hachimura H
FAU - Kuyama, Tomoko
AU  - Kuyama T
FAU - Amimoto, Akiteru
AU  - Amimoto A
FAU - Kumata, Tsuyoshi
AU  - Kumata T
FAU - Kitahara, Yuko
AU  - Kitahara Y
FAU - Takenaka, Masahiko
AU  - Takenaka M
FAU - Matsumura, Hitoshi
AU  - Matsumura H
FAU - Uno, Takehiro
AU  - Uno T
FAU - Uchino, Tomiya
AU  - Uchino T
FAU - Takehara, Kazutaka
AU  - Takehara K
FAU - Nishida, Kouji
AU  - Nishida K
FAU - Kadoya, Michiyo
AU  - Kadoya M
FAU - Sato, Masafumi
AU  - Sato M
FAU - Kato, Kaoru
AU  - Kato K
FAU - Matsumoto, Kanako
AU  - Matsumoto K
FAU - Saito, Satoshi
AU  - Saito S
FAU - Shimoda, Tetsuya
AU  - Shimoda T
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Vet Dermatol
JT  - Veterinary dermatology
JID - 9426187
RN  - 0 (Recombinant Proteins)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Dermatitis, Atopic/drug therapy/*veterinary
MH  - Dog Diseases/*drug therapy
MH  - Dogs
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Interferon-gamma/administration & dosage/*therapeutic use
MH  - Male
MH  - Recombinant Proteins
EDAT- 2009/08/27 09:00
MHDA- 2010/06/03 06:00
CRDT- 2009/08/27 09:00
PHST- 2009/08/27 09:00 [entrez]
PHST- 2009/08/27 09:00 [pubmed]
PHST- 2010/06/03 06:00 [medline]
AID - VDE764 [pii]
AID - 10.1111/j.1365-3164.2009.00764.x [doi]
PST - ppublish
SO  - Vet Dermatol. 2010 Feb;21(1):42-9. doi: 10.1111/j.1365-3164.2009.00764.x.