PMID- 1970605
OWN - NLM
STAT- MEDLINE
DCOM- 19900606
LR  - 20191101
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 10
IP  - 5
DP  - 1990 May
TI  - Potassium conductance increased by noradrenaline, opioids, somatostatin, and 
      G-proteins: whole-cell recording from guinea pig submucous neurons.
PG  - 1675-82
AB  - Agonists at alpha 2-adrenoceptors, delta-opioid receptors, and somatostatin 
      receptors were applied to dissociated guinea pig submucous plexus neurons; 
      whole-cell recordings of membrane current showed that they increased the membrane 
      potassium conductance. The conductance affected showed inward rectification, 
      being described by Gag(max)/[1 + exp((V - V0.5)/k)] where V0.5 was about -65 mV 
      and Gag(max) was about 10 nS. The agonists were ineffective when the potassium 
      conductance of the neurons had first been increased by intracellular dialysis 
      with purified guanosine 5'-triphosphate (GTP)-binding proteins (Gi or Go). 
      Agonist actions were prevented by pertussis toxin, applied intracellularly 
      (10-100 ng/ml for several minutes) or extracellularly 1-10 micrograms/ml for 1 
      hr); in the latter case, the agonist responses were reconstituted by 
      intracellular dialysis with GTP-binding proteins.
FAU - Tatsumi, H
AU  - Tatsumi H
AD  - Vollum Institute, Oregon Health Sciences University, Portland 97201.
FAU - Costa, M
AU  - Costa M
FAU - Schimerlik, M
AU  - Schimerlik M
FAU - North, R A
AU  - North RA
LA  - eng
GR  - DA03160/DA/NIDA NIH HHS/United States
GR  - DK32979/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Adrenergic alpha-Agonists)
RN  - 0 (Enkephalins)
RN  - 0 (Narcotics)
RN  - 0 (Receptors, Adrenergic, alpha)
RN  - 0 (Receptors, Opioid)
RN  - 0 (Receptors, Opioid, delta)
RN  - 0 (Thionucleotides)
RN  - 0 (Virulence Factors, Bordetella)
RN  - 37589-80-3 (Guanosine 5'-O-(3-Thiotriphosphate))
RN  - 51110-01-1 (Somatostatin)
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - EC 2.4.2.31 (Pertussis Toxin)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
RN  - RWP5GA015D (Potassium)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adrenergic alpha-Agonists/pharmacology
MH  - Animals
MH  - Dialysis
MH  - Electric Conductivity
MH  - Enkephalins/pharmacology
MH  - GTP-Binding Proteins/*pharmacology
MH  - Guanosine 5'-O-(3-Thiotriphosphate)
MH  - Guanosine Triphosphate/analogs & derivatives/pharmacology
MH  - Guinea Pigs
MH  - Narcotics/*pharmacology
MH  - Neurons/physiology
MH  - Norepinephrine/*pharmacology
MH  - Pertussis Toxin
MH  - Potassium/*physiology
MH  - Receptors, Adrenergic, alpha/physiology
MH  - Receptors, Opioid/physiology
MH  - Receptors, Opioid, delta
MH  - Somatostatin/*pharmacology
MH  - Submucous Plexus/cytology/*physiology
MH  - Thionucleotides/pharmacology
MH  - Time Factors
MH  - Virulence Factors, Bordetella/pharmacology
PMC - PMC6570076
EDAT- 1990/05/01 00:00
MHDA- 1990/05/01 00:01
PMCR- 1990/11/01
CRDT- 1990/05/01 00:00
PHST- 1990/05/01 00:00 [pubmed]
PHST- 1990/05/01 00:01 [medline]
PHST- 1990/05/01 00:00 [entrez]
PHST- 1990/11/01 00:00 [pmc-release]
AID - 10.1523/JNEUROSCI.10-05-01675.1990 [doi]
PST - ppublish
SO  - J Neurosci. 1990 May;10(5):1675-82. doi: 10.1523/JNEUROSCI.10-05-01675.1990.