PMID- 19706640
OWN - NLM
STAT- MEDLINE
DCOM- 20091105
LR  - 20220316
IS  - 1532-2092 (Electronic)
IS  - 1099-5129 (Linking)
VI  - 11
IP  - 9
DP  - 2009 Sep
TI  - Electrocardiographic algorithm to identify the optimal target ablation site for 
      idiopathic right ventricular outflow tract ventricular premature contraction.
PG  - 1214-20
LID - 10.1093/europace/eup231 [doi]
AB  - AIMS: Several electrocardiographic (ECG) algorithms have been developed to 
      identify the site of origin of ventricular premature contractions (VPCs) from 
      right ventricular outflow tract (RVOT) based on pacemapping; however, their 
      accuracy remains unclear. METHODS AND RESULTS: We evaluated the accuracy of these 
      algorithms in 52 consecutive patients (31 female, mean age 42.6+/-14.6 years) 
      with successful radiofrequency ablation of RVOT-VPC as guided by 3D 
      electroanatomical non-contact mapping (Ensite, St Jude Medical, USA) and compared 
      with a newly proposed ECG algorithm. As guided by 3D electroanatomical mapping, 
      the successful ablation sites of RVOT-VPC were RVOT septum (n=31), RVOT free wall 
      (n=19), and His region (n=2). Retrospective evaluation in the initial 39 patients 
      shows that the overall positive prediction value to identify a successful 
      ablation site of this newly proposed ECG algorithm is 77.3% and is higher than 
      the 73.3% by Ito et al., 73.3% by Joshi et al., and 53.8% by Dixit et al. 
      (P>0.05). Prospective evaluation in the subsequent 13 patients also demonstrate 
      similar high overall sensitivity (79.0%), specificity (92.7%), and positive 
      prediction value (88.2%) to identify a successful ablation site with this newly 
      proposed ECG algorithm. CONCLUSION: On the basis of detail 3D electroanatomical 
      mapping of successful ablation sites, a newly proposed ECG algorithm was 
      developed to improve the sensitivity, specificity, and positive prediction value 
      in identification of targeted ablation sites for RVOT-VPC.
FAU - Zhang, Fengxiang
AU  - Zhang F
AD  - Cardiovascular Medical Center of Jiangsu, First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, China.
FAU - Chen, Minglong
AU  - Chen M
FAU - Yang, Bing
AU  - Yang B
FAU - Ju, Weizhu
AU  - Ju W
FAU - Chen, Hongwu
AU  - Chen H
FAU - Yu, Jian
AU  - Yu J
FAU - Lau, Chu-Pak
AU  - Lau CP
FAU - Cao, Kejiang
AU  - Cao K
FAU - Tse, Hung-Fat
AU  - Tse HF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Europace
JT  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal 
      of the working groups on cardiac pacing, arrhythmias, and cardiac cellular 
      electrophysiology of the European Society of Cardiology
JID - 100883649
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Algorithms
MH  - Body Surface Potential Mapping/*methods
MH  - Catheter Ablation/*methods
MH  - Electrocardiography/methods
MH  - Heart Conduction System/surgery
MH  - Humans
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Surgery, Computer-Assisted/*methods
MH  - Treatment Outcome
MH  - Ventricular Outflow Obstruction/complications/*diagnosis/*surgery
MH  - Ventricular Premature Complexes/*diagnosis/etiology/*surgery
MH  - Young Adult
EDAT- 2009/08/27 09:00
MHDA- 2009/11/06 06:00
CRDT- 2009/08/27 09:00
PHST- 2009/08/27 09:00 [entrez]
PHST- 2009/08/27 09:00 [pubmed]
PHST- 2009/11/06 06:00 [medline]
AID - eup231 [pii]
AID - 10.1093/europace/eup231 [doi]
PST - ppublish
SO  - Europace. 2009 Sep;11(9):1214-20. doi: 10.1093/europace/eup231.