PMID- 19707110
OWN - NLM
STAT- MEDLINE
DCOM- 20091026
LR  - 20091014
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 338
IP  - 4
DP  - 2009 Oct
TI  - Serum immunoglobulin E can predict minimal change disease before renal biopsy.
PG  - 264-7
LID - 10.1097/MAJ.0b013e3181b471e4 [doi]
AB  - OBJECTIVES: Minimal change disease (MCD) is a major cause of nephrotic syndrome 
      in both children and adults. The diagnosis of MCD in adults relies on findings of 
      renal biopsy. Complications, although rare, may occur. This invasive procedure is 
      also a suffering experience for some patients. Although Shu et al described the 
      increase of serum immunoglobulin E (IgE) level in patients with MCD, whether IgE 
      could be a predicting factor of MCD has not been determined. METHODS: The sample 
      was composed of 76 nonlupus patients with nephrotic range (>or=3.5 g/d/1.73 m) 
      proteinuria and normal creatinine level who received renal biopsy since January 
      2006 to December 2007. Twenty-four demographic, clinical, and laboratory 
      variables as predictors of MCD, including IgG, IgA, IgM, and IgE, were 
      retrospectively gathered by chart review 1 day before renal biopsy. RESULTS: The 
      overall prevalence of MCD in this group (nonlupus and normal creatinine level) 
      was 27.6% (21 of 76). The independent Student t test identified that 3 of 24 
      variables is statistically significant (P < 0.05). Serum IgE was found to have a 
      good discriminative power (area under the receiver operating characteristic curve 
      0.868 +/- 0.053; P < 0.001) according to the area under the receiver operating 
      characteristic curve. CONCLUSIONS: Serum IgE exhibited high discriminative power 
      in predicting MCD. Serum IgE is a straightforward and easily applied evaluative 
      tool with good predictive abilities.
FAU - Shao, Yen-Ning
AU  - Shao YN
AD  - Department of Nephrology, Renal Research Center, Chang Gung Memorial Hospital, 
      Chang Gung University College of Medicine, Taipei, Taiwan.
FAU - Chen, Yung-Chang
AU  - Chen YC
FAU - Jenq, Chang-Chyi
AU  - Jenq CC
FAU - Hsu, Hsiang-Hao
AU  - Hsu HH
FAU - Chang, Ming-Yang
AU  - Chang MY
FAU - Tian, Ya-Chung
AU  - Tian YC
FAU - Fang, Ji-Tseng
AU  - Fang JT
FAU - Yang, Chih-Wei
AU  - Yang CW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - *Biopsy
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Nephrosis, Lipoid/*diagnosis/pathology
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
EDAT- 2009/08/27 09:00
MHDA- 2009/10/27 06:00
CRDT- 2009/08/27 09:00
PHST- 2009/08/27 09:00 [entrez]
PHST- 2009/08/27 09:00 [pubmed]
PHST- 2009/10/27 06:00 [medline]
AID - S0002-9629(15)31794-8 [pii]
AID - 10.1097/MAJ.0b013e3181b471e4 [doi]
PST - ppublish
SO  - Am J Med Sci. 2009 Oct;338(4):264-7. doi: 10.1097/MAJ.0b013e3181b471e4.