PMID- 19708125
OWN - NLM
STAT- MEDLINE
DCOM- 20090910
LR  - 20220330
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1792
IP  - 3
DP  - 2009 Mar
TI  - Tumor necrosis factor alpha -308 gene locus promoter polymorphism: an analysis of 
      association with health and disease.
PG  - 163-72
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a potent immunomediator and 
      proinflammatory cytokine that has been implicated in the pathogenesis of a large 
      number of human diseases. The location of its gene within major 
      histocompatibility complex and biological activities has raised the possibility 
      that polymorphisms within this locus may contribute to the pathogenesis of wide 
      range of autoimmune and infectious diseases. For example, a bi-allelic single 
      nucleotide substitution of G (TNFA1 allele) with A (TNFA2 allele) polymorphism at 
      -308 nucleotides upstream from the transcription initiation site in the TNF-alpha 
      promoter is associated with elevated TNF-alpha levels and disease 
      susceptibilities. However, it is still unclear whether TNF-alpha -308 
      polymorphism plays a part in the disease process, in particular whether it could 
      affect transcription factor binding and in turn influence TNF-alpha transcription 
      and synthesis. Several studies have suggested that TNFA2 allele is significantly 
      linked with the high TNF-alpha-producing autoimmune MHC haplotype HLA-A1, B8, 
      DR3, with elevated serum TNF-alpha levels and a more severe outcome in diseases. 
      This review discusses the genetics of the TNF-alpha -308 polymorphism in selected 
      major diseases and evaluates its common role in health and disease.
FAU - Elahi, Maqsood M
AU  - Elahi MM
AD  - Department of Human Sciences, Human Genetics Laboratory, Loughborough University, 
      Leicestershire, UK.
FAU - Asotra, Kamlesh
AU  - Asotra K
FAU - Matata, Bashir M
AU  - Matata BM
FAU - Mastana, Sarabjit S
AU  - Mastana SS
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Cytokines)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Cytokines/metabolism
MH  - Disease/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Inflammation/immunology
MH  - Nutrigenomics
MH  - *Polymorphism, Genetic
MH  - *Promoter Regions, Genetic
MH  - Transcriptional Activation
MH  - Tumor Necrosis Factor-alpha/*genetics/metabolism
RF  - 97
EDAT- 2009/08/27 09:00
MHDA- 2009/09/11 06:00
CRDT- 2009/08/27 09:00
PHST- 2009/08/27 09:00 [entrez]
PHST- 2009/08/27 09:00 [pubmed]
PHST- 2009/09/11 06:00 [medline]
AID - S0925-4439(09)00022-2 [pii]
AID - 10.1016/j.bbadis.2009.01.007 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2009 Mar;1792(3):163-72. doi: 10.1016/j.bbadis.2009.01.007.