PMID- 19708173
OWN - NLM
STAT- MEDLINE
DCOM- 20090908
LR  - 20191111
IS  - 1341-8076 (Print)
IS  - 1341-8076 (Linking)
VI  - 35
IP  - 2
DP  - 2009 Apr
TI  - Soluble tumor necrosis factor receptor-I in preterm infants with 
      chorioamnionitis.
PG  - 252-7
AB  - AIM: The aim of our study was (i) to determine whether chorioamnionitis (CAM) is 
      associated with an elevated soluble tumor necrosis factor receptor I (sTNFR-I) 
      level and (ii) to examine the time course of the concentration of sTNFR-I in 
      preterm infants after birth. METHODS: We measured sTNFR-I levels in the cord 
      blood of 112 preterm infants (gestational age < or =34 weeks), and those in 
      peripheral blood of 30 preterm infants on days 7, 14, 21 and 28. RESULTS: The 
      median value for the sTNFR-I was significantly elevated in 33 infants with CAM at 
      stage 3 (4618 pg/mL) compared with the 52 infants without CAM (2866 pg/mL), or 
      the 13 infants with CAM at stage 1 (3638 pg/mL) and the 14 infants at stage 2 
      (3242 pg/mL). The severity of CAM is an independent factor for the elevation of 
      cord blood sTNFR-I. The sTNFR-I level on day 0 was significantly higher in eight 
      infants with CAM at stage 3 than in the 22 infants without CAM or with CAM at 
      stage 1 and 2; however there were no significant differences on days 7, 14, 21 
      and 28. The serum level of sTNFR-I showed a significant gradual decline with 
      time. CONCLUSIONS: We suggest that there is an association between elevated 
      sTNFR-I levels in cord blood and maternal CAM, and this elevation may reflect the 
      fetal inflammation. However the elevation of sTNFR-I could not persist 
      postnatally for a long time.
FAU - Sato, Miho
AU  - Sato M
AD  - Maternity and Neonate Center, Yokohama City University Medical Center, Japan.
FAU - Nishimaki, Shigeru
AU  - Nishimaki S
FAU - An, Hiromi
AU  - An H
FAU - Shima, Yoshio
AU  - Shima Y
FAU - Naruto, Takuya
AU  - Naruto T
FAU - Sugai, Toshiyuki
AU  - Sugai T
FAU - Iwasaki, Shiho
AU  - Iwasaki S
FAU - Seki, Kazuo
AU  - Seki K
FAU - Imagawa, Tomoyuki
AU  - Imagawa T
FAU - Mori, Masaaki
AU  - Mori M
FAU - Yokota, Shumpei
AU  - Yokota S
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Obstet Gynaecol Res
JT  - The journal of obstetrics and gynaecology research
JID - 9612761
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
SB  - IM
MH  - Chorioamnionitis/*blood
MH  - Female
MH  - Fetal Blood/*chemistry
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Pregnancy
MH  - Receptors, Tumor Necrosis Factor, Type I/*blood
EDAT- 2009/08/27 09:00
MHDA- 2009/09/09 06:00
CRDT- 2009/08/27 09:00
PHST- 2009/08/27 09:00 [entrez]
PHST- 2009/08/27 09:00 [pubmed]
PHST- 2009/09/09 06:00 [medline]
AID - 10.1111/j.1447-0756.2008.00949.x [doi]
PST - ppublish
SO  - J Obstet Gynaecol Res. 2009 Apr;35(2):252-7. doi: 
      10.1111/j.1447-0756.2008.00949.x.