PMID- 19710347
OWN - NLM
STAT- MEDLINE
DCOM- 20091006
LR  - 20090827
IS  - 0956-4624 (Print)
IS  - 0956-4624 (Linking)
VI  - 20
IP  - 9
DP  - 2009 Sep
TI  - Pneumocystis-associated organizing pneumonia as a manifestation of immune 
      reconstitution inflammatory syndrome in an HIV-infected individual with a normal 
      CD4+ T-cell count following antiretroviral therapy.
PG  - 662-5
LID - 10.1258/ijsa.2008.008428 [doi]
AB  - We describe a rare case of Pneumocystic jirovecii-associated organizing pneumonia 
      (PJP) in an HIV-infected individual on highly active antiretroviral therapy 
      (HAART) with a CD4(+) T-cell count of 835 x 10(3) cells/mL and a low viral load. 
      PJP was confirmed using transbronchial biopsies and bronchoalveolar lavage. The 
      presentation in this patient suggests immune reconstitution inflammatory syndrome 
      (IRIS) after institution of antiretroviral therapy (ART). This case report, 
      however, is the first documented presentation of PJP in a patient with CD4 count 
      greater than 300 prior to the induction of HAART who developed PJP and organizing 
      pneumonia as a manifestation of IRIS. This suggests that there is continuing 
      immune dysfunction in the face of re-expansion of CD4(+) T-cells and low viral 
      load in HIV patients despite ART.
FAU - Mori, S
AU  - Mori S
AD  - Internal Medicine, The University of Texas Health Sciences Center Houston, 
      Houston, Texas 77030, USA. shahram.mori@uth.tmc.edu
FAU - Polatino, S
AU  - Polatino S
FAU - Estrada-Y-Martin, R M
AU  - Estrada-Y-Martin RM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Int J STD AIDS
JT  - International journal of STD & AIDS
JID - 9007917
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*etiology
MH  - Adult
MH  - Antiretroviral Therapy, Highly Active
MH  - CD4 Lymphocyte Count
MH  - HIV Infections/drug therapy/*immunology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*complications
MH  - Male
MH  - Pneumonia, Pneumocystis/*etiology
EDAT- 2009/08/28 09:00
MHDA- 2009/10/07 06:00
CRDT- 2009/08/28 09:00
PHST- 2009/08/28 09:00 [entrez]
PHST- 2009/08/28 09:00 [pubmed]
PHST- 2009/10/07 06:00 [medline]
AID - 20/9/662 [pii]
AID - 10.1258/ijsa.2008.008428 [doi]
PST - ppublish
SO  - Int J STD AIDS. 2009 Sep;20(9):662-5. doi: 10.1258/ijsa.2008.008428.