PMID- 1971112
OWN - NLM
STAT- MEDLINE
DCOM- 19900618
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 35
IP  - 3
DP  - 1990 Mar
TI  - Tolerance and cross-tolerance to 3,4-methylenedioxymethamphetamine (MDMA), 
      methamphetamine and methylenedioxyamphetamine.
PG  - 637-42
AB  - The effects of (+-)-3,4-methylenedioxymethamphetamine (MDMA) (0.62-20.0 mg/kg), 
      (+)-methamphetamine (MA) (0.62-5.0 mg/kg) and (+/-)-3,4-methylenedioxyamphetamine 
      (MDA) (0.62-5.0 mg/kg) on milk intake in rats were determined before and during a 
      period of repeated daily administration of MDMA. Experimental sessions consisted 
      of 15-min access to a sweetened milk solution each day, 5 days a week. After 
      initial determination of the effects of MDMA, MA and MDA on milk intake, rats 
      were injected daily with either MDMA (2.5-5.0 mg/kg) or saline. Two groups of 
      rats were injected with MDMA, one group 15 min before, and the other group 15 min 
      after the milk-drinking sessions. Two more groups of rats were injected with 
      saline, one group 15 min before, and the other group 15 min after the sessions. 
      During this repeated administration period the effects of MDMA, MA and MDA 
      (injected 15 min prior to the session) were redetermined. In rats that had been 
      injected with MDMA on a daily basis either before or after the milk-drinking 
      sessions, the dose-response function of MDMA was shifted to the right, indicating 
      that tolerance had developed. Cross-tolerance to MA appeared to develop only in 
      the group of rats that had been injected with MDMA on a daily basis before the 
      milk-drinking sessions. Cross-tolerance to MDA did not develop in any of the 4 
      groups of rats.
FAU - Zacny, J P
AU  - Zacny JP
AD  - Drug Abuse Research Center, Pritzker School of Medicine, University of Chicago, 
      IL 60637.
FAU - Virus, R M
AU  - Virus RM
FAU - Woolverton, W L
AU  - Woolverton WL
LA  - eng
GR  - DA-00085/DA/NIDA NIH HHS/United States
GR  - DA-00250/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Amphetamines)
RN  - 44RAL3456C (Methamphetamine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Drinking Behavior/drug effects
MH  - Drug Tolerance
MH  - Male
MH  - Methamphetamine/*pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1990/03/01 00:00
MHDA- 1990/03/01 00:01
CRDT- 1990/03/01 00:00
PHST- 1990/03/01 00:00 [pubmed]
PHST- 1990/03/01 00:01 [medline]
PHST- 1990/03/01 00:00 [entrez]
AID - 0091-3057(90)90301-W [pii]
AID - 10.1016/0091-3057(90)90301-w [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1990 Mar;35(3):637-42. doi: 
      10.1016/0091-3057(90)90301-w.