PMID- 1971133
OWN - NLM
STAT- MEDLINE
DCOM- 19900620
LR  - 20190918
IS  - 0340-6075 (Print)
IS  - 0340-6075 (Linking)
VI  - 58
IP  - 5
DP  - 1990
TI  - Morphological changes in cerebral vascular smooth muscle cells in stroke-prone 
      spontaneously hypertensive rats (SHRSP). A scanning and transmission electron 
      microscopic study.
PG  - 377-82
AB  - The ultrastructure of the vascular smooth muscle cells of the middle cerebral 
      artery in 6-month-old male stroke-prone spontaneously hypertensive rats (SHRSP) 
      was studied by scanning (SEM) and transmission electron microscopy (TEM) and 
      compared with that of age-matched normotensive Wistar Kyoto rats (WKY). Although 
      the smooth muscle cells of WKY rats by SEM had a typical spindle shape and smooth 
      surface texture, those of SHRSP were structurally modified by numerous surface 
      invaginations and projections, bearing some structural resemblance to the 
      myotendinous junction of skeletal muscle. Structural modifications affected more 
      than half the surface of medial smooth muscle cells in SHRSP, but less than 0.6% 
      of the surface of these cells in WKY rats. About 10% of medial smooth muscle 
      cells were necrotic in SHRSP, but no necrotic cells were identified in WKY rats. 
      By TEM, smooth muscle cells in SHRSP were shown to be irregular in profile with 
      deep indentations of the plasma membrane and were surrounded by many layers of 
      basal lamina-like material. The present study suggests that most smooth muscle 
      cells in the middle cerebral artery of SHRSP may be modified to adapt to chronic 
      hypertension by increasing the junctional area between muscle cells and 
      connective tissue and that some cells may undergo necrosis.
FAU - Fujiwara, T
AU  - Fujiwara T
AD  - Laboratory Animal Center, Ehime University School of Medicine, Japan.
FAU - Kondo, M
AU  - Kondo M
FAU - Tabei, R
AU  - Tabei R
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Virchows Arch B Cell Pathol Incl Mol Pathol
JT  - Virchows Archiv. B, Cell pathology including molecular pathology
JID - 9316922
SB  - IM
MH  - Animals
MH  - Cerebral Arteries/cytology/*pathology/ultrastructure
MH  - Cerebrovascular Disorders/etiology/*pathology
MH  - Disease Susceptibility
MH  - Hypertension/complications/*pathology
MH  - Male
MH  - Microscopy, Electron
MH  - Microscopy, Electron, Scanning
MH  - Muscle, Smooth, Vascular/cytology/*pathology/ultrastructure
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.1007/BF02890095 [doi]
PST - ppublish
SO  - Virchows Arch B Cell Pathol Incl Mol Pathol. 1990;58(5):377-82. doi: 
      10.1007/BF02890095.