PMID- 1971219
OWN - NLM
STAT- MEDLINE
DCOM- 19900628
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 177
IP  - 1-2
DP  - 1990 Feb 20
TI  - 5-hydroxytryptamine uptake blockers attenuate the 5-hydroxytryptamine-releasing 
      effect of 3,4-methylenedioxymethamphetamine and related agents.
PG  - 95-8
AB  - This study examined the [3H]5-HT-releasing properties of 
      3,4-methylenedioxymethamphetamine (MDMA) and related agents, all of which cause 
      significant release of [3H]5-HT from rat brain synaptosomes. 5-HT uptake blockers 
      dose dependently block MDMA-induced [3H]5-HT release. The EC50s of the uptake 
      drugs in blocking MDMA-induced release correlate with their affinity for the 5-HT 
      uptake site labeled by [3H]paroxetine (r = 0.98; P less than 0.01). These data 
      demonstrate that the 5-HT uptake carrier plays a significant role in the release 
      of 5-HT induced by MDMA and related agents.
FAU - Hekmatpanah, C R
AU  - Hekmatpanah CR
AD  - Department of Neurology, Stanford University Medical Center, CA 94305.
FAU - Peroutka, S J
AU  - Peroutka SJ
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Amphetamines)
RN  - 0 (Piperidines)
RN  - 0 (Serotonin Antagonists)
RN  - 333DO1RDJY (Serotonin)
RN  - 41VRH5220H (Paroxetine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*antagonists & 
      inhibitors/pharmacology
MH  - Amphetamines/*antagonists & inhibitors
MH  - Animals
MH  - Brain Chemistry/drug effects
MH  - In Vitro Techniques
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Paroxetine
MH  - Piperidines/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/*metabolism
MH  - Serotonin Antagonists/*pharmacology
MH  - Synaptosomes/drug effects/metabolism
EDAT- 1990/02/20 00:00
MHDA- 1990/02/20 00:01
CRDT- 1990/02/20 00:00
PHST- 1990/02/20 00:00 [pubmed]
PHST- 1990/02/20 00:01 [medline]
PHST- 1990/02/20 00:00 [entrez]
AID - 0014-2999(90)90555-K [pii]
AID - 10.1016/0014-2999(90)90555-k [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1990 Feb 20;177(1-2):95-8. doi: 10.1016/0014-2999(90)90555-k.