PMID- 19712260
OWN - NLM
STAT- MEDLINE
DCOM- 20091214
LR  - 20221207
IS  - 1440-1797 (Electronic)
IS  - 1320-5358 (Linking)
VI  - 14
IP  - 6
DP  - 2009 Sep
TI  - Association of interleukin-18 promoter polymorphism and atherosclerotic diseases 
      in Chinese patients with diabetic nephropathy.
PG  - 606-12
LID - 10.1111/j.1440-1797.2008.01075.x [doi]
AB  - AIM: Interleukin-18 (IL-18) is a pro-inflammatory cytokine and possibly plays an 
      important role in the pathogenesis of cardiovascular disease. The relationship 
      between two IL-18 gene polymorphisms, namely C-607A and G-137C, and 
      cardiovascular disease in patients with diabetic nephropathy was examined. 
      METHODS: Two hundred and twenty patients (91 male) with diabetic nephropathy were 
      studied. The IL-18 promoter genotypes were determined. All patients were then 
      prospectively followed for the cardiovascular events. Cardiovascular mortality 
      and all-cause mortality were also compared. RESULTS: Mean age was 64.3 +/- 10.6 
      years; average follow up was 73.9 +/- 33.6 months. The frequencies of CC, CA and 
      AA genotypes of the C-607A polymorphism were 25.5%, 48.2% and 26.8%, 
      respectively; GG, GC and CC genotypes of the G-137C polymorphism were 71.8%, 
      25.0% and 3.2%, respectively. Neither of the polymorphisms were associated with 
      the development of primary cardiovascular end-point. Cardiovascular survival was 
      84.8% and 70.6% at 60 months for GG and GC/CC genotypes of the G-137C 
      polymorphism, respectively (P = 0.027); the corresponding actuarial survival was 
      69.0% and 54.8%, respectively (P = 0.053). However, the G-137C genotype was not 
      an independent predictor of cardiovascular or actuarial survival after adjusting 
      for confounders by multivariate analysis with the Cox model. The C-607A 
      polymorphism had no significant effect on cardiovascular or actuarial survival. 
      CONCLUSION: The G-137C polymorphism of the IL-18 promoter is associated with the 
      cardiovascular mortality, and a trend of association with all-cause mortality, in 
      patients with diabetic nephropathy. The association, however, becomes 
      insignificant after adjusting for confounding factors. Further studies are needed 
      to test other genetic determinants of the association between systemic 
      inflammation and cardiovascular disease in renal failure patients.
FAU - Szeto, Cheuk-Chun
AU  - Szeto CC
AD  - Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese 
      University of Hong Kong, Shatin, Hong Kong, China. ccszeto@cuhk.edu.hk
FAU - Chow, Kai-Ming
AU  - Chow KM
FAU - Poon, Peter Yam-Kau
AU  - Poon PY
FAU - Kwan, Bonnie Ching-Ha
AU  - Kwan BC
FAU - Li, Philip Kam-Tao
AU  - Li PK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Nephrology (Carlton)
JT  - Nephrology (Carlton, Vic.)
JID - 9615568
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Interleukin-18)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Atherosclerosis/*genetics
MH  - C-Reactive Protein/analysis
MH  - Cardiovascular Diseases/mortality
MH  - Diabetic Nephropathies/etiology/*genetics
MH  - Female
MH  - Genotype
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Promoter Regions, Genetic
MH  - Risk Factors
EDAT- 2009/08/29 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/08/29 09:00
PHST- 2009/08/29 09:00 [entrez]
PHST- 2009/08/29 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - NEP1075 [pii]
AID - 10.1111/j.1440-1797.2008.01075.x [doi]
PST - ppublish
SO  - Nephrology (Carlton). 2009 Sep;14(6):606-12. doi: 
      10.1111/j.1440-1797.2008.01075.x.