PMID- 19713679
OWN - NLM
STAT- MEDLINE
DCOM- 20100114
LR  - 20190727
IS  - 1349-3329 (Electronic)
IS  - 0040-8727 (Linking)
VI  - 219
IP  - 1
DP  - 2009 Sep
TI  - Elevated risk of motor vehicle accident for male drivers with obstructive sleep 
      apnea syndrome in the Tokyo metropolitan area.
PG  - 11-6
AB  - Previous studies have suggested that patients with obstructive sleep apnea 
      syndrome (OSAS) are at an increased risk of motor vehicle accidents (MVAs). This 
      study is the first systematic investigation of MVA risk among Japanese drivers 
      with obstructive sleep apnea syndrome (OSAS). We investigated the rate of MVAs in 
      the preceding 5 years and dozing off at the wheel in Japanese male OSAS drivers 
      (n = 616, mean [S.D.] age: 46.3 [10.1] years old) and age-matched male controls 
      (n = 600), and the characteristics of OSAS patients who experienced multiple MVAs 
      as well as the effectiveness of continuous positive airway pressure (CPAP) 
      treatment in reducing MVA risk. The odds ratio of MVA in the OSAS group compared 
      to a general population was 2.36. Multivariate logistic regression analysis 
      revealed that MVA was significantly associated with either subjective sleepiness 
      beyond normal limits (Epworth sleepiness scale: ESS > or = 11) or serious 
      respiratory disorders (apnea hypopnea index: AHI > or = 40). AHI scores were 
      significantly higher in the group with multiple MVAs than in those with a single 
      MVA, despite the ESS score in the former group being significantly lower. CPAP 
      treatment was effective for reduction of MVA. The MVA rate among OSAS patients in 
      the research area was significantly higher than that among the controls. 
      Subjective excessive daytime sleepiness and severity of OSAS are independently 
      associated with the occurrence of MVA. In conclusion, early diagnosis and 
      treatment of OSAS drivers especially with serious respiratory disorder should be 
      made to prevent multiple MVAs.
FAU - Komada, Yoko
AU  - Komada Y
AD  - Department of Somnology, Tokyo Medical University, Tokyo, Japan. 
      ykoma@tokyo-med.ac.jp
FAU - Nishida, Yasushi
AU  - Nishida Y
FAU - Namba, Kazuyoshi
AU  - Namba K
FAU - Abe, Takashi
AU  - Abe T
FAU - Tsuiki, Satoru
AU  - Tsuiki S
FAU - Inoue, Yuichi
AU  - Inoue Y
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Tohoku J Exp Med
JT  - The Tohoku journal of experimental medicine
JID - 0417355
SB  - IM
MH  - Accidents, Traffic/*statistics & numerical data
MH  - Adult
MH  - Continuous Positive Airway Pressure
MH  - Cross-Sectional Studies
MH  - Disorders of Excessive Somnolence/epidemiology/etiology
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Medical Records
MH  - Middle Aged
MH  - *Motor Vehicles
MH  - Odds Ratio
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Sleep Apnea, Obstructive/complications/diagnosis/*epidemiology/therapy
MH  - Surveys and Questionnaires
MH  - Tokyo/epidemiology
EDAT- 2009/08/29 09:00
MHDA- 2010/01/15 06:00
CRDT- 2009/08/29 09:00
PHST- 2009/08/29 09:00 [entrez]
PHST- 2009/08/29 09:00 [pubmed]
PHST- 2010/01/15 06:00 [medline]
AID - JST.JSTAGE/tjem/219.11 [pii]
AID - 10.1620/tjem.219.11 [doi]
PST - ppublish
SO  - Tohoku J Exp Med. 2009 Sep;219(1):11-6. doi: 10.1620/tjem.219.11.