PMID- 19714864
OWN - NLM
STAT- MEDLINE
DCOM- 20090917
LR  - 20171116
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1790
IP  - 4
DP  - 2009 Apr
TI  - Olive phenols efficiently inhibit the oxidation of serum albumin-bound linoleic 
      acid and butyrylcholine esterase.
PG  - 240-8
LID - 10.1016/j.bbagen.2009.01.007 [doi]
AB  - BACKGROUND: Olive phenols are widely consumed in the Mediterranean diet and can 
      be detected in human plasma. Here, the capacity of olive phenols and plasma 
      metabolites to inhibit lipid and protein oxidations is investigated in two plasma 
      models. METHODS: The accumulation of lipid oxidation products issued from the 
      oxidation of linoleic acid bound to human serum albumin (HSA) by AAPH-derived 
      peroxyl radicals is evaluated in the presence and absence of phenolic 
      antioxidants. Phenol binding to HSA is addressed by quenching of the Trp214 
      fluorescence and displacement of probes (quercetin, dansylsarcosine and 
      dansylamide). Next, the esterase activity of HSA-bound butyrylcholine esterase 
      (BChE) is used as a marker of protein oxidative degradation. RESULTS: 
      Hydroxytyrosol, oleuropein, caffeic and chlorogenic acids inhibit lipid 
      peroxidation as well as HSA-bound BChE as efficiently as the potent flavonol 
      quercetin. Hydroxycinnamic derivatives bind noncompetitively HSA subdomain IIA 
      whereas no clear site could be identified for hydroxytyrosol derivatives. GENERAL 
      SIGNIFICANCE: In both models, olive phenols and their metabolites are much more 
      efficient inhibitors of lipid and protein oxidations compared to vitamins C and 
      E. Low postprandial concentrations of olive phenols may help to preserve the 
      integrity of functional proteins and delay the appearance of toxic lipid 
      oxidation products.
FAU - Roche, Marjolaine
AU  - Roche M
AD  - UMR408 Safety and Quality of Plant Products, INRA, University of Avignon, Domaine 
      St Paul, Avignon, France.
FAU - Dufour, Claire
AU  - Dufour C
FAU - Loonis, Michele
AU  - Loonis M
FAU - Reist, Marianne
AU  - Reist M
FAU - Carrupt, Pierre-Alain
AU  - Carrupt PA
FAU - Dangles, Olivier
AU  - Dangles O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Antioxidants)
RN  - 0 (Phenols)
RN  - 0 (Serum Albumin)
RN  - 9KJL21T0QJ (Linoleic Acid)
RN  - EC 3.1.1.8 (Butyrylcholinesterase)
SB  - IM
MH  - Antioxidants/*pharmacology
MH  - Butyrylcholinesterase/*metabolism
MH  - Humans
MH  - Kinetics
MH  - Linoleic Acid/*chemistry
MH  - Lipid Peroxidation/drug effects
MH  - Models, Chemical
MH  - Olea/*chemistry
MH  - Oxidation-Reduction
MH  - Phenols/*chemistry/*pharmacology
MH  - Serum Albumin/*chemistry
EDAT- 2009/08/29 09:00
MHDA- 2009/09/18 06:00
CRDT- 2009/08/29 09:00
PHST- 2009/08/29 09:00 [entrez]
PHST- 2009/08/29 09:00 [pubmed]
PHST- 2009/09/18 06:00 [medline]
AID - S0304-4165(09)00010-5 [pii]
AID - 10.1016/j.bbagen.2009.01.007 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2009 Apr;1790(4):240-8. doi: 10.1016/j.bbagen.2009.01.007.