PMID- 19715553
OWN - NLM
STAT- MEDLINE
DCOM- 20100621
LR  - 20191027
IS  - 1875-5828 (Electronic)
IS  - 1567-2050 (Linking)
VI  - 7
IP  - 2
DP  - 2010 Mar
TI  - Genetic susceptibility to behavioural and psychological symptoms in Alzheimer 
      disease.
PG  - 158-64
AB  - Alzheimer's disease (AD) is a neurodegenerative disorder characterized by 
      progressive cognitive decline including loss of memory, orientation and 
      reasoning. However, a relevant aspect of AD is the presence of a variety of 
      behavioural and psychological symptoms in dementia (BPSD), beyond the well-known 
      progressive cognitive impairment. Approximately 50% to 80% of patients diagnosed 
      with AD present behavioural or psychiatric disturbances such as psychosis, 
      depression, agitation, disinhibition, aggression, hyperactivity, and socially 
      intrusive behaviours. These symptoms may be burdensome for physicians and 
      caregivers and lead to earlier institutionalization and increased social and 
      economic costs. In this view, recent literature has considered the likely genetic 
      component of BPSD in AD, defining different clusters. Several studies have 
      investigated whether the main recognised genetic risk factor for late-onset AD, 
      namely the apolipoprotein E (APOE) gene, is associated with BPSD, with 
      conflicting results. The involvement of dopamine- or serotonin-related pathways 
      and associated genetic variabilities has been demonstrated as being interesting 
      candidates for the neuropsychiatry manifestations of dementia. Moreover, genetic 
      variations of neurotrophins, such as brain-derived neurotrophic factor (BDNF), 
      have been related to depression susceptibility in AD. In the present review, we 
      summarise the current literature on genetic risk factors to BPSD susceptibility 
      in AD and discuss future possible treatment strategies.
FAU - Borroni, Barbara
AU  - Borroni B
AD  - Centre for Brain Aging and Neurodegenerative Disorders, Department of Neurology, 
      University of Brescia, Italy. bborroni@inwind.it
FAU - Costanzi, Chiara
AU  - Costanzi C
FAU - Padovani, Alessandro
AU  - Padovani A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Alzheimer Res
JT  - Current Alzheimer research
JID - 101208441
RN  - 0 (Apolipoproteins E)
RN  - 0 (Biogenic Monoamines)
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Alzheimer Disease/*genetics/physiopathology/*psychology
MH  - Animals
MH  - Apolipoproteins E/genetics
MH  - Biogenic Monoamines/metabolism
MH  - Brain Chemistry/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Mice
MH  - Nerve Growth Factors/genetics
MH  - Neural Pathways/metabolism/physiopathology
MH  - Neurocognitive Disorders/*genetics/physiopathology
MH  - Polymorphism, Genetic/genetics
RF  - 81
EDAT- 2009/09/01 06:00
MHDA- 2010/06/22 06:00
CRDT- 2009/09/01 09:00
PHST- 2008/12/05 00:00 [received]
PHST- 2009/03/10 00:00 [accepted]
PHST- 2009/09/01 09:00 [entrez]
PHST- 2009/09/01 06:00 [pubmed]
PHST- 2010/06/22 06:00 [medline]
AID - CAR-10 [pii]
AID - 10.2174/156720510790691173 [doi]
PST - ppublish
SO  - Curr Alzheimer Res. 2010 Mar;7(2):158-64. doi: 10.2174/156720510790691173.