PMID- 19716042
OWN - NLM
STAT- MEDLINE
DCOM- 20100111
LR  - 20121115
IS  - 1557-3117 (Electronic)
IS  - 1053-2498 (Linking)
VI  - 28
IP  - 9
DP  - 2009 Sep
TI  - Exercise performance in patients with pulmonary hypertension linked to cardiac 
      magnetic resonance measures.
PG  - 899-905
LID - 10.1016/j.healun.2009.05.004 [doi]
AB  - BACKGROUND: The 6-minute walk distance (6MWD) is a useful measure of functional 
      class and has been shown to predict mortality in patients with pulmonary 
      hypertension (PH). Determinants of functional class in PH are incompletely 
      understood. We hypothesized that cardiovascular structure and function, as 
      determined by cardiac magnetic resonance (CMR) imaging, and cardiac hemodynamics, 
      as determined by right heart catheterization (RHC), would predict 6MWD in adult 
      patients with PH. METHODS: Forty-three patients (32 women) with PH underwent RHC, 
      CMR and 6MWD testing within a 3-month period. The 6MWD was correlated with RHC 
      and CMR variables using Spearman rho (r) coefficients. These relationships were 
      further evaluated using linear regression analysis. RESULTS: Median 6MWD was 
      233.2 (interquartile range 161.6 to 338.4) meters. The 6MWD was correlated with 
      pulmonary artery (PA) elasticity (r = 0.42, p = 0.006), PA average blood flow 
      velocity (r = 0.38, p = 0.014), right ventricular stroke volume index (RVSVI; r = 
      0.41, p = 0.008), left ventricular SVI (LVSVI; r = 0.36, p = 0.018) and RV stroke 
      work index (RVSWI; r = 0.37, p = 0.017). These associations remained significant 
      after adjustment for age, gender, body mass index and the presence of lung 
      disease. Exercise performance did not correlate with commonly measured indices 
      such as ventricular volume, ejection fraction or pulmonary pressure. CONCLUSIONS: 
      Stroke volume index, PA elasticity and PA average blood flow velocity are novel 
      CMR parameters associated with functional class in PH. CMR can provide insights 
      into determinants of exercise performance and may be a useful tool to 
      non-invasively monitor cardiovascular status in patients with PH.
FAU - Stevens, Gerin R
AU  - Stevens GR
AD  - Zena and Michael A. Wiener Cardiovascular Institute and Marie-Josee and Henry R. 
      Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New 
      York, New York, USA. grs2123@columbia.edu
FAU - Lala, Anuradha
AU  - Lala A
FAU - Sanz, Javier
AU  - Sanz J
FAU - Garcia, Mario J
AU  - Garcia MJ
FAU - Fuster, Valentin
AU  - Fuster V
FAU - Pinney, Sean
AU  - Pinney S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the 
      International Society for Heart Transplantation
JID - 9102703
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Cardiac Catheterization
MH  - Exercise/*physiology
MH  - Female
MH  - Heart/anatomy & histology/*physiopathology
MH  - Heart Diseases/complications
MH  - Humans
MH  - Hypertension, Pulmonary/etiology/pathology/*physiopathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Regression Analysis
MH  - Stroke Volume
MH  - Systole
MH  - Vascular Resistance
MH  - Ventricular Function, Left
MH  - Walking/*physiology
EDAT- 2009/09/01 06:00
MHDA- 2010/01/12 06:00
CRDT- 2009/09/01 09:00
PHST- 2009/03/17 00:00 [received]
PHST- 2009/04/23 00:00 [revised]
PHST- 2009/05/02 00:00 [accepted]
PHST- 2009/09/01 09:00 [entrez]
PHST- 2009/09/01 06:00 [pubmed]
PHST- 2010/01/12 06:00 [medline]
AID - S1053-2498(09)00321-0 [pii]
AID - 10.1016/j.healun.2009.05.004 [doi]
PST - ppublish
SO  - J Heart Lung Transplant. 2009 Sep;28(9):899-905. doi: 
      10.1016/j.healun.2009.05.004.