PMID- 19719987
OWN - NLM
STAT- MEDLINE
DCOM- 20100107
LR  - 20131121
IS  - 0253-3758 (Print)
IS  - 0253-3758 (Linking)
VI  - 37
IP  - 2
DP  - 2009 Feb
TI  - [Association of serum uric acid, plasma NT-proBNP, Hs-C reactive protein and 
      invasive hemodynamic parameters in patients with heart failure].
PG  - 126-9
AB  - OBJECTIVE: To explore the correlation of serum uric acid, invasive hemodynamic 
      parameters, plasma N-terminal proBNP (NT-proBNP) and Hs-C reactive protein 
      (Hs-CRP) in patients with heart failure. METHOD: Invasive hemodynamic parameters 
      derived from Swan-Ganz catheter, serum uric acid, plasma NT-proBNP and Hs-CRP 
      within 12 hours after hospital admission were analyzed in 141 patients with 
      chronic heart failure [New York Heart Association (NYHA) class II-IV]. RESULTS: 
      Incidence of hyperuricemia was 55.30% in this patient cohort. Pulmonary capillary 
      wedge pressure (PCWP) and plasma NT-proBNP in hyperuricemia patients were 
      significantly higher than those in non-hyperuricemia patients (P < 0.01). The 
      percentages of high plasma NT-proBNP (> 600 pmol/L) and hyperuricemia were 
      significantly higher in patients with PCWP > or = 18 and < 28 mm Hg (1 mm Hg = 
      0.133 kPa) and patients with PCWP > or = 28 mm Hg compared those in patients with 
      PCWP < 18 mm Hg, (P = 0.01, P = 0.02; P < 0.01, P < 0.01, respectively). Partial 
      correlation analysis showed that serum uric acid correlated with right atrial 
      pressure, right ventricular pressure, pulmonary arterial pressure and PCWP (r = 
      0.19, P = 0.03; r = 0.45, P < 0.01; r = 0.23, P = 0.01; r = 0.24, P = 0.01, 
      respectively). Multiple linear regression analysis showed both serum uric acid 
      and plasma NT-proBNP correlated independently with PCWP (beta = 0.24, P = 0.01; 
      beta = 0.47, P < 0.01, respectively) while plasma Hs-CRP and left ventricular 
      ejection fraction were not correlated with serum uric acid and PCWP (P > 0.05). 
      CONCLUSION: Serum uric acid independently correlated with PCWP in patients with 
      heart failure and the combined measurements of serum uric acid and plasma 
      NT-proBNP are helpful in evaluating the prognosis of patients with heart failure.
FAU - Zhang, Yu-Hui
AU  - Zhang YH
AD  - Department of Cardiology, Cardiovascular Institute and Fuwai Hospital, Chinese 
      Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, 
      China.
FAU - Lu, Rong
AU  - Lu R
FAU - Zhao, Xue-Yan
AU  - Zhao XY
FAU - Kang, Lian-Ming
AU  - Kang LM
FAU - Yang, Yue-Jin
AU  - Yang YJ
FAU - Zhang, Jian
AU  - Zhang J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Xin Xue Guan Bing Za Zhi
JT  - Zhonghua xin xue guan bing za zhi
JID - 7910682
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 268B43MJ25 (Uric Acid)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - C-Reactive Protein/*metabolism
MH  - Female
MH  - Heart Failure/*blood
MH  - Hemodynamics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - Prognosis
MH  - Uric Acid/*blood
MH  - Young Adult
EDAT- 2009/09/02 06:00
MHDA- 2010/01/08 06:00
CRDT- 2009/09/02 09:00
PHST- 2009/09/02 09:00 [entrez]
PHST- 2009/09/02 06:00 [pubmed]
PHST- 2010/01/08 06:00 [medline]
PST - ppublish
SO  - Zhonghua Xin Xue Guan Bing Za Zhi. 2009 Feb;37(2):126-9.