PMID- 19720920
OWN - NLM
STAT- MEDLINE
DCOM- 20091026
LR  - 20211020
IS  - 1527-7755 (Electronic)
IS  - 0732-183X (Print)
IS  - 0732-183X (Linking)
VI  - 27
IP  - 28
DP  - 2009 Oct 1
TI  - Health-related quality of life among long-term rectal cancer survivors with an 
      ostomy: manifestations by sex.
PG  - 4664-70
LID - 10.1200/JCO.2008.20.9502 [doi]
AB  - PURPOSE: Intestinal stomas can pose significant challenges for long-term (> or = 
      5 years) rectal cancer (RC) survivors. Specifying common challenges and 
      sociodemographic or clinical differences will further the development of tailored 
      interventions to improve health-related quality of life (HRQOL). PATIENTS AND 
      METHODS: This was a matched cross-sectional study of long-term RC survivors 
      conducted in three Kaiser Permanente regions. The mailed questionnaire included 
      the modified City of Hope Quality of Life-Ostomy (mCOH-QOL-Ostomy) and Medical 
      Outcomes Study 36-Item Short-Form Health Survey, version 2 (SF-36v2). Groups 
      surveyed were permanent ostomates (cases) and those who did not require an ostomy 
      (controls). RC survivors were matched on sex, age, and time since diagnosis. 
      Comparisons between groups used regression analysis with adjustment for age, 
      comorbidity score, history of radiation therapy, income, and work status. 
      RESULTS: Response rate was 54% (491 of 909). Cases and controls had similar 
      demographic characteristics. On the basis of the mCOH-QOL-Ostomy, both male and 
      female cases had significantly worse social well-being compared with controls, 
      while only female cases reported significantly worse overall HRQOL and 
      psychological well-being. For younger females (< age 75 years), ostomy had a 
      greater impact on physical well-being compared with older females. Based on the 
      SF-36v2, statistically significant and meaningful differences between female 
      cases and controls were observed for seven of the eight scales and on the 
      physical and mental component summary scores. CONCLUSION: Men and women report a 
      different profile of challenges, suggesting the need for targeted or sex-specific 
      interventions to improve HRQOL in this population. This may include focus on 
      physical HRQOL for female ostomy survivors younger than age 75.
FAU - Krouse, Robert S
AU  - Krouse RS
AD  - Southern Arizona Veterans Affairs Health Care System, Tucson, AZ 85723, USA. 
      robert.krouse@va.gov
FAU - Herrinton, Lisa J
AU  - Herrinton LJ
FAU - Grant, Marcia
AU  - Grant M
FAU - Wendel, Christopher S
AU  - Wendel CS
FAU - Green, Sylvan B
AU  - Green SB
FAU - Mohler, M Jane
AU  - Mohler MJ
FAU - Baldwin, Carol M
AU  - Baldwin CM
FAU - McMullen, Carmit K
AU  - McMullen CK
FAU - Rawl, Susan M
AU  - Rawl SM
FAU - Matayoshi, Eric
AU  - Matayoshi E
FAU - Coons, Stephen Joel
AU  - Coons SJ
FAU - Hornbrook, Mark C
AU  - Hornbrook MC
LA  - eng
GR  - P30 CA023074/CA/NCI NIH HHS/United States
GR  - R01 CA106912/CA/NCI NIH HHS/United States
GR  - R01 CA106912-01/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090831
PL  - United States
TA  - J Clin Oncol
JT  - Journal of clinical oncology : official journal of the American Society of 
      Clinical Oncology
JID - 8309333
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Ostomy/methods/*statistics & numerical data
MH  - *Quality of Life
MH  - Rectal Neoplasms/psychology/*surgery
MH  - Sex Factors
MH  - Surveys and Questionnaires
MH  - Survivors/psychology/*statistics & numerical data
PMC - PMC2754912
COIS- Authors' disclosures of potential conflicts of interest and author contributions 
      are found at the end of this article.
EDAT- 2009/09/02 06:00
MHDA- 2009/10/27 06:00
PMCR- 2010/10/01
CRDT- 2009/09/02 09:00
PHST- 2009/09/02 09:00 [entrez]
PHST- 2009/09/02 06:00 [pubmed]
PHST- 2009/10/27 06:00 [medline]
PHST- 2010/10/01 00:00 [pmc-release]
AID - JCO.2008.20.9502 [pii]
AID - 09502 [pii]
AID - 10.1200/JCO.2008.20.9502 [doi]
PST - ppublish
SO  - J Clin Oncol. 2009 Oct 1;27(28):4664-70. doi: 10.1200/JCO.2008.20.9502. Epub 2009 
      Aug 31.