PMID- 19722841
OWN - NLM
STAT- MEDLINE
DCOM- 20091022
LR  - 20101230
IS  - 1746-0921 (Electronic)
IS  - 1746-0913 (Linking)
VI  - 4
IP  - 7
DP  - 2009 Sep
TI  - Pathogen recognition by DC-SIGN shapes adaptive immunity.
PG  - 879-90
LID - 10.2217/fmb.09.51 [doi]
AB  - Dendritic cells (DCs) tailor adaptive immune responses to specific pathogens. 
      This diversity is mediated by cooperation between different pattern recognition 
      receptors that are triggered by specific pathogens. DC-specific intercellular 
      adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is a pattern recognition 
      receptor with a broad pathogen recognition specificity as a result of its 
      affinity for mannose and fucose carbohydrates. DC-SIGN induces very diverse 
      immune responses to different pathogens, such as bacteria, fungi, helminths and 
      viruses. Recent data show that DC-SIGN triggering by pathogens modulates 
      Toll-like receptor signaling at the level of nuclear factor-kappaB. In this 
      article, we will discuss the signaling pathways induced by DC-SIGN and its 
      central role in the regulation of adaptive immunity to bacterial, fungal and 
      viral pathogens.
FAU - Geijtenbeek, Teunis B H
AU  - Geijtenbeek TB
AD  - Department of Molecular Cell Biology & Immunology, VU University Medical Center, 
      1007 MC Amsterdam, The Netherlands. t.b.geijtenbeek@amc.uva.nl
FAU - den Dunnen, Jeroen
AU  - den Dunnen J
FAU - Gringhuis, Sonja I
AU  - Gringhuis SI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Future Microbiol
JT  - Future microbiology
JID - 101278120
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Animals
MH  - Bacteria/immunology
MH  - Cell Adhesion Molecules/*immunology
MH  - Dendritic Cells/*immunology
MH  - Fungi/immunology
MH  - Helminths/immunology
MH  - Humans
MH  - Lectins, C-Type/*immunology
MH  - Models, Biological
MH  - Receptors, Cell Surface/*immunology
MH  - *Signal Transduction
MH  - Viruses/immunology
RF  - 94
EDAT- 2009/09/03 06:00
MHDA- 2009/10/23 06:00
CRDT- 2009/09/03 09:00
PHST- 2009/09/03 09:00 [entrez]
PHST- 2009/09/03 06:00 [pubmed]
PHST- 2009/10/23 06:00 [medline]
AID - 10.2217/fmb.09.51 [doi]
PST - ppublish
SO  - Future Microbiol. 2009 Sep;4(7):879-90. doi: 10.2217/fmb.09.51.