PMID- 19727837
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20220316
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Linking)
VI  - 25
IP  - 1
DP  - 2010 Jan
TI  - Outcomes of kidney transplant tourism in children: a single center experience.
PG  - 155-9
LID - 10.1007/s00467-009-1303-x [doi]
AB  - Transplant tourism is a necessity for children with end-stage renal disease 
      living in regions without established local transplantation programs. The use of 
      kidneys from living unrelated donors (LURDs) was common practice in Asia prior to 
      the recent global condemnation of commercial organ transplantation. Objective 
      information on the outcomes of pediatric transplant tourism is scarce. Here, we 
      report the Dubai experience with 45 renal allograft transplantations performed 
      outside the United Arab Emirates (UAE) between 1993 and 2009. Transplantation 
      from 33 LURDs, ten living related donors (LRDs) and two deceased donors was 
      performed in 14 different countries. The mean number of human leukocyte antigen 
      (HLA) A/B/DR allele matches was 1.4 +/- 0.8 in the LURD graft recipients and 3.9 
      +/- 0.7 in the LRD recipients. Outcomes were compared with those of a matched 
      group of 3,150 pediatric LRD transplantations from the Collaborative Transplant 
      Study (CTS). Ten-year patient survival was 100% in the LRD patients, 91.2% in the 
      LURD patients, and 92% in the CTS patients. The three deaths in the LURD group 
      occurred within the first 4 months after transplantation and were related to 
      acute rejection. One-year and 10-year graft survival was 100% in the LRD group 
      and 94.8% and 66.7% in the CTS-LRD groups, vs 87.8% and 43.4% in the LURD group. 
      Major viral infections [Epstein-Barr virus (EBV), cytomegalovirus (CMV), 
      varicella zoster (VZV)] were four-times more common in patients that had received 
      LURD grafts than in those that had received LRD grafts. In conclusion, whereas 
      LRD kidney transplantation performed abroad yields excellent long-term results, 
      transplantation of LURD kidneys is fraught with a high complication rate 
      affecting graft and even early patient survival.
FAU - Majid, Abdul
AU  - Majid A
AD  - Division of Pediatric Nephrology, Dubai Hospital, Dubai, United Arab Emirates.
FAU - Al Khalidi, Lina
AU  - Al Khalidi L
FAU - Ahmed, Bushra Q
AU  - Ahmed BQ
FAU - Opelz, Gerhard
AU  - Opelz G
FAU - Schaefer, Franz
AU  - Schaefer F
LA  - eng
PT  - Journal Article
DEP - 20090901
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Graft Rejection/drug therapy/immunology
MH  - Graft Survival
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Kidney Diseases/immunology/mortality/*surgery
MH  - *Kidney Transplantation
MH  - *Living Donors
MH  - Male
MH  - *Medical Tourism
MH  - Survival Rate
MH  - *Tissue and Organ Procurement
MH  - Treatment Outcome
MH  - United Arab Emirates/epidemiology
EDAT- 2009/09/04 06:00
MHDA- 2011/06/29 06:00
CRDT- 2009/09/04 06:00
PHST- 2009/06/24 00:00 [received]
PHST- 2009/07/28 00:00 [accepted]
PHST- 2009/07/27 00:00 [revised]
PHST- 2009/09/04 06:00 [entrez]
PHST- 2009/09/04 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - 10.1007/s00467-009-1303-x [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2010 Jan;25(1):155-9. doi: 10.1007/s00467-009-1303-x. Epub 2009 
      Sep 1.